1350899-02-3Relevant articles and documents
Design, synthesis and in vitro trypanocidal and leishmanicidal activities of novel semicarbazone derivatives
Alves, Marina A.,De Queiroz, Aline C.,Alexandre-Moreira, Magna Suzana,Varela, Javier,Cerecetto, Hugo,González, Mercedes,Doriguetto, Antonio C.,Landre, Iara M.,Barreiro, Eliezer J.,Lima, Lídia M.
, p. 24 - 33 (2015)
Trypanosomatids are protozoan parasites that cause various diseases in human, such as leishmaniasis, Chagas disease and sleeping sickness. The highly syntenic genomes of the trypanosomatid species lead the assumption that they can encode similar proteins,
Synthesis and characterization of vanillin semicarbazones
Venkateshhan,Ravichandiran,Selvakumar,Lavakumar
, p. 4632 - 4634 (2012/02/04)
Semicarbazones have a great interest because of their chemistry and biological activities for the treatment of various human ailments. A series of seven vanillin semicarbazones (3a-g) were synthesized by reflux of aryl semicarbazides with appropriate carbonyl compound in the presence of glacial acetic acid. The aryl semicarbazides (2a-g) were synthesized from aryl carbamates by reacting with hydrazine hydrate and ethanol on hydrazinolysis. The aryl carbamates (1a-g) were obtained by the reaction between phenyl chloro formate and aniline/substituted aniline in anhydrous ether in the presence of sodium hydroxide. The structure of the newly synthesized compounds was established by various analytical techniques such as IR, 1H NMR and MASS spectral studies.
