1350913-08-4

Basic information

• Product Name: N-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-aMine
• Synonyms: N-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-aMine;2-(Methylamino)pyridine-4-boronic acid pinacol ester
• CAS NO: 1350913-08-4
• Molecular Formula: C₁₂H₁₉BN₂O₂
• Molecular Weight: 234.10246
• EINECS: 200-258-5
• Product Categories: 6
• Mol File: 1350913-08-4.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: N-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-aMine(1350913-08-4)
• EPA Substance Registry System: N-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-aMine(1350913-08-4)

Safety Data

• Hazardous Substances Data: 1350913-08-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
N-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-aMine is utilized as a key intermediate in the synthesis of pharmaceutical drugs. Its reactivity allows for the creation of a wide range of drug molecules, contributing to the development of new treatments and therapies.
Used in Chemical Research:
In the field of chemical research, N-Methyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-aMine serves as a valuable compound for studying reaction mechanisms and exploring new synthetic pathways. Its complex structure provides opportunities for researchers to investigate its properties and potential applications in various chemical processes.

Upstream product

• 73183-34-3 bis(pinacol)diborane 
• 468718-65-2 N-(4-bromopyridin-2-yl)-N-methylamine 

Downstream Products

• 1374328-50-3 N-methyl-4-phenylpyridin-2-amine 

Relevant articles and documents

HETEROCYCLIC INHIBITORS OF ATR KINASE

The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of ATR kinase for the treatment or prevention of cancer.

Synthesis of biaryls through a one-pot tandem borylation/Suzuki-Miyaura cross-coupling reaction catalyzed by a palladacycle

The tricyclohexylphosphane adduct of cyclopalladated ferrocenylimine I exhibited high catalytic activity in the one-pot borylation/Suzuki-Miyaura coupling (BSC) reaction with low catalyst loading (2 mol-%). Various biaryls were obtained in good to excellent yields for 37 examples. This process was applied to aryl and heteroaryl halides (Br and Cl) containing a variety of functional groups and did not require an excess amount of phosphane ligand and the addition of the palladium catalyst in the second step. Cyclopalladated ferrocenylimine I exhibited high catalytic activity in the borylation/Suzuki- Miyaura coupling (BSC) reaction with low catalyst loading. Various unsymmetrical biaryls were obtained ingood to excellent yields in one pot. This protocol was applied to aryl and heteroaryl halides (Br and Cl) containing a variety of functional groups without adding catalyst in the second step. Copyright