1350980-63-0

Basic information

• Product Name: cyclopropyl N-(1-oxyl-4'-demethyl-4-deoxypodophyllic)-L-valine amide
• Synonyms: cyclopropyl N-(1-oxyl-4'-demethyl-4-deoxypodophyllic)-L-valine amide
• CAS NO: 1350980-63-0
• Molecular Weight: 566.608
• Mol File: 1350980-63-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: cyclopropyl N-(1-oxyl-4'-demethyl-4-deoxypodophyllic)-L-valine amide(CAS DataBase Reference)
• NIST Chemistry Reference: cyclopropyl N-(1-oxyl-4'-demethyl-4-deoxypodophyllic)-L-valine amide(1350980-63-0)
• EPA Substance Registry System: cyclopropyl N-(1-oxyl-4'-demethyl-4-deoxypodophyllic)-L-valine amide(1350980-63-0)

Safety Data

• Hazardous Substances Data: 1350980-63-0(Hazardous Substances Data)

Upstream product

• 518-28-5 podofilox 
• 13734-41-3 t-Boc-L-valine 
• 6559-91-7 4'-demethylepipodophyllotoxin 
• 3590-93-0 4'-demethyl-4-deoxypodophyllotoxin 
• 1350980-67-4 C₁₃H₂₄N₂O₃ 
• 1308813-97-9 4'-demethyl-4-deoxypodophyllotoxin 4'-(p-nitrophenyl) carbonate 
• 214139-86-3 C₈H₁₆N₂O 

Relevant articles and documents

Carbamates of 4′-demethyl-4-deoxypodophyllotoxin: Synthesis, cytotoxicity and cell cycle effects

In an attempt to generate compounds with superior bioactivity and reduced toxicity, 12 carbamates of 4′-demethyl-4-deoxypodophyllotoxin, N-(1-oxyl-4′-demethyl- 4-deoxypodophyllic)-α-amino acids amides, were synthesized and evaluated for antiproliferative activity and cell cycle effects. These synthesized compounds proved to be more hydrophilic, as well as improved or comparable in vitro cytotoxicities against four cell lines (A-549, HeLa, SiHa, and HL-60) compared with either parent DPT or anti-cancer drug VP-16. Furthermore, flow cytometric analysis exhibited that N-(1-oxyl-4′- demethyl-4-deoxypodophyllic)-d-α-methine amide (15f) induced cell cycle arrest in the G2/M phase in A-549 cells.