135103-73-0

Upstream product

• 729-81-7 1,3,5-tris(trifluoromethyl)benzene 
• 444-40-6 2,4,6-tris(trilfuoromethyl)phenyllithium 
• 75-36-5 acetyl chloride 

Downstream Products

• 114071-25-9 (Z)-4-Hydroxy-4-(2,4,6-tris-trifluoromethyl-phenyl)-but-3-en-2-one 

Relevant academic research and scientific papers

The 2,4,6-tris(trifluoromethyl)phenyl group: Methyl and vinyl ketones and related chemistry

2,4,6-Tris(trifluoromethyl)phenyllithium (1) reacts with acetaldehyde and acrolein to give the corresponding alcohols 5 and 8. Oxidation of the alcohols with the CrO3-pyridine complex affords the acetophenone 3 and the vinyl ketone 7 respectively. The reactions of 1 with trifluoroacetic anhydride and trimethylsilyl trifluoroacetate give low to moderate yields of the trifluoroacetophenone 6.

New Aspects of the Chemistry of 2,4,6-Tris(trifluoromethyl) Benzoic Acid and Related Compounds

1,3,5-Tris(trifluoromethyl)benzene reacts with n-butyllithium and carbon dioxide to give a high yield of 2,4,6-tris(trifluoromethyl)benzoic acid.The acid has been well characterized by spectral and pKa data.The acid chloride is formed only slow