1351186-35-0

Basic information

• Product Name: (3R,4S,6R)-8-((R)-N,2-dimethylbutanamido)-3,4,6-trimethyl-N-((R)-1-(tritylthio)but-3-en-2-yl)octanamide
• CAS NO: 1351186-35-0
• Molecular Weight: 626.947
• Mol File: 1351186-35-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3R,4S,6R)-8-((R)-N,2-dimethylbutanamido)-3,4,6-trimethyl-N-((R)-1-(tritylthio)but-3-en-2-yl)octanamide(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,4S,6R)-8-((R)-N,2-dimethylbutanamido)-3,4,6-trimethyl-N-((R)-1-(tritylthio)but-3-en-2-yl)octanamide(1351186-35-0)
• EPA Substance Registry System: (3R,4S,6R)-8-((R)-N,2-dimethylbutanamido)-3,4,6-trimethyl-N-((R)-1-(tritylthio)but-3-en-2-yl)octanamide(1351186-35-0)

Safety Data

• Hazardous Substances Data: 1351186-35-0(Hazardous Substances Data)

Upstream product

• 158861-38-2 (R)-N-methyl-N-methoxy-2-tert-butoxycarbonylamino-3-(triphenylmethylthio)propionamide 
• 1351186-27-0 (R)-N,2-dimethyl-N-((3R,5S,6R)-3,5,6-trimethyl-8-oxo-8-((R)-2-oxo-4-phenyloxazolidin-3-yl)octyl)butanamide 
• 1351186-44-1 (R)-1-(tritylthio)but-3-en-2-amine 
• 1352233-31-8 (R)-tert-butyl (1-(tritylthio)but-3-en-2-yl)carbamate 
• 1351186-14-5 (R)-3-(tert-butoxycarbonylamino)-4-(tritylthio)but-1-en-2-yl trifluoromethanesulfonate 

Downstream Products

• 1352308-28-1 (R)-N,2-dimethyl-N-((3R,5S,6R)-3,5,6-trimethyl-7-((R)-4-vinyl-4,5-dihydrothiazol-2-yl)heptyl)butanamide 

Relevant articles and documents

Synthesis and biological activity of kalkitoxin and its analogues

Total syntheses of kalkitoxin, isolated from the Caribbean Lyngbya majuscula, and its analogues, 3-epi-, 7-epi-, 8-epi-, 10-epi-, 10-nor-, and 16-nor-kalkitoxin, were achieved via oxazolidinone-based diastereoselective 1,4-addition reaction of a methyl group and efficient TiCl4-mediated thiazoline ring formation as the key steps. The biological activities of synthetic kalkitoxin and its analogues were evaluated with brine shrimp.