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13515-06-5

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13515-06-5 Usage

Uses

5,6-Dimethylpyrazine-2-carboxylic Acid is used in the synthetic preparation of pyrazine biosynthesis in Corynebacterium glutamicum.

Check Digit Verification of cas no

The CAS Registry Mumber 13515-06-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,5,1 and 5 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 13515-06:
(7*1)+(6*3)+(5*5)+(4*1)+(3*5)+(2*0)+(1*6)=75
75 % 10 = 5
So 13515-06-5 is a valid CAS Registry Number.

13515-06-5Relevant articles and documents

Hederagenin compound H-X with anti-lung cancer effect and preparation method and application thereof

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Paragraph 0048; 0049; 0051; 0052; 0120; 0121, (2020/04/17)

The invention provides a hederagenin compound H-X with an anti-tumor effect and a preparation method and application thereof. The structural general formula 1 is shown in the specifications. Most of the derivatives provided by the invention have obvious inhibition effects on tumor cells A549, MCF-7 and HepG2, and the compound hederagenin-2, 6-dimethylpyrazine (H-08) shows good selectivity betweentumors and normal conditions, especially on lung cancer A549 cells. The IC50 of the compound to A549, MCF-7, HepG2, MDCK and H9c2 is 3.45+/-0.59 muM, 8.73+/-1.49 muM, 8.71+/-0.38 muM, 14.11+/-0.04 muM, and 16.69+/-0.12 muM, the inhibition effect on A549 cells is similar to that of a positive drug cis-platinum (IC50 is 3.85+/-0.63 muM), but the toxicity on MDCK and H9c2 is obviously lower than thatof cis-platinum.

Pyrazine biosynthesis in corynebacterium glutamicum

Dickschat, Jeroen S.,Wickel, Susanne,Bolten, Christoph J.,Nawrath, Thorben,Schulz, Stefan,Wittmann, Christoph

supporting information; experimental part, p. 2687 - 2695 (2010/08/07)

The volatile compounds released by Corynebacterium glutamicum were collected by use of the CLSA technique (closed-loop stripping apparatus) and analysed by GC-MS. The headspace extracts contained several acyloins and pyrazines that were identified by their synthesis or comparison to commercial standards. Feeding experiments with [2H7]acetoin resulted in the incorporation of labelling into trimethylpyrazine and tetramethylpyrazine. Several deletion mutants targeting genes of the primary metabolism, were constructed to elucidate the biosynthetic pathway to pyrazines in detail. A deletion mutant of the ketol-acid reductoisomerase was not able to convert the acetoin precursor (S)2-acetolactate into the pathway intermediate (R)-2,3-dihydroxy-3-methylbutanoate to the branched amino acids. This mutant requires valine, leucine, and isoleucine for growth and produces significantly higher amounts and more different compounds of the acyloin and pyrazine classes. Gene deletion of the acetolactate synthase (AS) resulted in a mutant that is not able to convert pyruvate into (5)-2-acetolactate. This mutant also requires branched amino acids and produces only very small amounts of pyrazines likely from valine via the valine biosynthetic pathway operating in reverse order. A ΔASΔKR double mutant was constructed that does not produce any pyrazines at all. These results open up a detailed biosynthetic model for the formation of alkylated pyrazines via acyloins.

Enzymatische Oxidation von Methylgruppen an Heteroarenen: eine vielseitige Methode zur Herstellung heteroaromatischer Carbonsaeuren

Kiener, Andreas

, p. 748 - 749 (2007/10/02)

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