54897-59-5

Basic information

• Product Name: DL-2,3-DIAMINOPROPIONIC ACID MONOHYDROCHLORIDE
• Synonyms: DL-ALPHA-BETA-DIAMINOPROPIONIC ACID HYDROCHLORIDE;DL-3-AMINOALANINE HYDROCHLORIDE;DL-2,3-DIAMINOPROPIONIC ACID HYDROCHLORIDE;DL-2,3-DIAMINOPROPIONIC ACID MONOHYDROCHLORIDE;2,3-DIAMINOPROPIONIC ACID MONOHYDROCHLORIDE;3-AMINO-DL-ALANINE HYDROCHLORIDE;3-AMINO-DL-ALANINE MONOHYDROCHLORIDE;3-amino-dl-alaninmonohydrochloride
• CAS NO: 54897-59-5
• Molecular Formula: C₃H₈N₂O₂*2ClH
• Molecular Weight: 140.57
• EINECS: 259-387-1
• Product Categories: Amino Acid Derivatives
• Mol File: 54897-59-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 231-233 °C (dec.)
• Boiling Point: 325.6 °C at 760 mmHg
• Flash Point: 150.7 °C
• Appearance: White to slightly beige/Fine Crystalline Powder
• Storage Temp.: 0-6°C
• Water Solubility: almost transparency
• Merck: 14,2984
• BRN: 5293359
• CAS DataBase Reference: DL-2,3-DIAMINOPROPIONIC ACID MONOHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: DL-2,3-DIAMINOPROPIONIC ACID MONOHYDROCHLORIDE(54897-59-5)
• EPA Substance Registry System: DL-2,3-DIAMINOPROPIONIC ACID MONOHYDROCHLORIDE(54897-59-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• F: 3-10
• Hazardous Substances Data: 54897-59-5(Hazardous Substances Data)

Usage

Chemical Properties

white to slightly beige fine crystalline powder

Uses

Dl-2,3-Diaminopropionic Acid, Hydrochloride can be used for pharmaceutical composition for viral infections.

InChI:InChI=1/C3H8N2O2.ClH/c1-3(4,5)2(6)7;/h4-5H2,1H3,(H,6,7);1H

Upstream product

• 171514-08-2 methyl (R)-(-)-3-acetamido-2-aminopropanoate 
• 756440-66-1 3-Amino-2-benzoylamino-propionic acid methyl ester 
• 337368-14-6 (S)-3-[(phenylmethyloxy)amino]-N-[(phenylmethyloxy)carbonyl]alanine 

Downstream Products

• 145489-09-4 bis-Fmoc-2,3-diaminopropanoic acid 
• 13534-76-4 6-phenylpyrazine-2-carboxylic acid 
• 13534-77-5 5-phenylpyrazine-2-carboxylic acid 
• 159652-30-9 (R)-2,3-bis-tert-butoxycarbonylaminopropionic acid 
• 127689-48-9 staphyloferrin B 
• 13515-06-5 5,6-Dimethylpyrazin-2-carbonsaeure 
• 1166831-52-2 6-{4-[trans-4-(methoxycarbonyl)cyclohexyl]phenyl}-5-methylpyrazine-2-carboxylic acid 
• 25880-75-5 dichloro((d,l)-diaminopropionic acid)platinum(II) 
• 6059-44-5 methyl 2,3-diaminopropanoate dihydrochloride 
• 548760-13-0 5,6-bis(4-chlorophenyl)-pyrazine-2-carboxylic acid 
• 119929-06-5 N,N'-bis(p-toluenesulfonyl)-2,3-diaminopropionic acid 
• 7464-90-6 butyl DL-2,3-diaminopropionate dihydrochloride 
• 126581-99-5 DPAB-L-DPA (trans) 
• 42548-08-3 (+/-)-N,N'-dicarbobenzyloxy-2,3-diaminopropanoic acid 

Relevant articles and documents

Crystallization Does It All: An Alternative Strategy for Stereoselective Aza-Henry Reaction

An efficient and experimentally straightforward method for the stereoselective synthesis of a variety of β-nitro-α-amino carboxylic acids via aza-Henry (nitro-Mannich) reaction of aldimines is disclosed, yielding either anti- or a rarely reported syn-configuration. The reaction operates directly on free glyoxylic acid and generates imine species in situ. Crystallization-controlled diastereoselectivity enables isolation of the target compounds in high enantio- and diastereomeric purities by a simple filtration.

Preparation method and application of D-dencichine

The invention discloses a preparation method and application of D-dencichine. The preparation method comprises the following steps: carrying out Fmoc protection on the amino group of D-asparagine so as to obtain a first intermediate; subjecting the first intermediate to Hoffman degradation reaction so as to obtain a second intermediate; subjecting the second intermediate to removal of Fmoc protection under the action of organic base so as to obtain a third intermediate; and subjecting the third intermediate and monomethyl oxalate to condensation reaction under a highly basic condition so as to obtain D-dencichine. D-dencichine is prepared by using the high-efficiency safe preparation method; the preparation method is simple and has high yield; the compound D-dencichine prepared by using the method has good treatment effect on thrombocytopenia and the effect is better than the effect of a clinical medicine interleukin-11, so D-dencichine can be used as a candidate medicine for treating thrombocytopenia.

A new and facile route for the synthesis of chiral 1,2-diamines and 2,3-diamino acids

The synthesis of chiral diamines and diamino acids has been achieved from the corresponding N-arylsulfonyl aziridines through reaction with a chiral isocyanate and subsequent hydrolysis of 2-imidazolidinones. The method appears to be general and of wide applicability.