13515-63-4Relevant articles and documents
Interaction of Monoamine Oxidase B with Analogues of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Derived from Prodine-Type Analgesics
Brossi, Arnold,Gessner, Wieslaw P.,Fritz, Richard R.,Bembenek, Michael E.,Abell, Creed W.
, p. 444 - 445 (1986)
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Synthesis and toxicity toward nigrostriatal dopamine neurons of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) analogues
Fries,De Vries,Hazelhoff,Horn
, p. 424 - 427 (2007/10/02)
Six compounds having structural features in common with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were synthesized and tested in mice for the ability to produce a prolonged decrease in nigrostriatal dopamine (DA) and DA metabolites. The compounds that were prepared and tested include the ester elimination products of the analgetic drugs α-prodine and trimeperidine. None of the compounds in this study, except for MPTP, produced significant neurotoxic effects in the mouse model. The study shows that minor changes in the tetrahydropyridine ring of MPTP result in a marked decrease in neurotoxicity.
Conversion of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its 5-Methyl Analog into Pyridinium Salts
Gessner, Wieslaw,Brossi, Arnold,Shen, Rong-sen,Fritz, Richard R.,Abell, Creed W.
, p. 2037 - 2042 (2007/10/02)
Monoamine oxidase B metabolizes 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP; 1) first to 1-methyl-4-phenyl-2,3-dihydropyridinium salt (MPDP+; 5), and then to 1-methyl-4-phenylpyridinium salt (MPP+; 7).Chemical synthesis of MPD
