1351512-17-8

Basic information

• Product Name: 3-cyclohexyl 6-ethyl 2-(2-phenylacetamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate
• Synonyms: 3-cyclohexyl 6-ethyl 2-(2-phenylacetamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate
• CAS NO: 1351512-17-8
• Molecular Weight: 470.59
• Mol File: 1351512-17-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-cyclohexyl 6-ethyl 2-(2-phenylacetamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-cyclohexyl 6-ethyl 2-(2-phenylacetamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate(1351512-17-8)
• EPA Substance Registry System: 3-cyclohexyl 6-ethyl 2-(2-phenylacetamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate(1351512-17-8)

Safety Data

• Hazardous Substances Data: 1351512-17-8(Hazardous Substances Data)

Upstream product

• 103-82-2 phenylacetic acid 
• 1351512-26-9 3-cyclohexyl 6-ethyl 2-amino-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate 
• 103-80-0 phenylacetyl chloride 
• 52688-11-6 cyclohexyl 2-cyanoacetate 
• 108-93-0 cyclohexanol 

Relevant articles and documents

Thiophene inhibitors of PDE4: Crystal structures show a second binding mode at the catalytic domain of PDE4D2

PDE4 inhibitors have been identified as therapeutic targets for a variety of conditions, particularly inflammatory diseases. We have serendipitously identified a novel class of phosphodiesterase 4 (PDE4) inhibitor during a study to discover antagonists of the parathyroid hormone receptor. X-ray crystallographic studies of PDE4D2 complexed to four potent inhibitors reveal the atomic details of how they inhibit the enzyme and a notable contrast to another recently reported thiophene-based inhibitor.