1351557-07-7Relevant articles and documents
One-pot access to indolo[2,3- b]quinolines by electrophile-triggered cross-amination/friedel-crafts alkylation of indoles with 1-(2-tosylaminophenyl) ketones
Ali, Shaukat,Li, Ying-Xiu,Anwar, Saeed,Yang, Fang,Chen, Zi-Sheng,Liang, Yong-Min
experimental part, p. 424 - 431 (2012/02/13)
Activation of C2 and C3 of indoles by molecular iodine (I2) and base followed by in situ reaction with 1-(2-tosylaminophenyl)ketones or 2-tosylaminobenzaldehyde can afford highly substituted indolo(2,3-b)quinolines in moderate to excellent yields (up to 99%). The reaction provides a metal-free selective difunctionalization of indoles. The synthetic potential of the protocol has been illustrated by the synthesis of neocryptolepine and its 11-methyl analogue.