1351557-38-4Relevant articles and documents
Synthesis of 5,7-diarylindoles: Via Suzuki-Miyaura coupling in water
Elumalai, Vijayaragavan,Hansen, J?rn H.
supporting information, p. 10343 - 10347 (2021/12/17)
The synthesis of novel 5,7-diaryl and diheteroaryl indoles has been explored via efficient double Suzuki-Miyaura coupling. The method notably employs a low catalyst loading of Pd(PPh3)4 (1.5 mol%/coupling) and water as the reaction solvent to obtain 5,7-diarylated indoles without using N-protecting groups in up to 91% yield. The approach is also suitable for N-protected and 3-substituted indoles and constitutes an important green and convenient arylation strategy for the benzenoid ring of indoles. The synthesized diarylindoles are fluorescent. This journal is
