1351785-53-9Relevant academic research and scientific papers
Enantioselective one-pot conjugate addition of Grignard reagents to cyclic enones followed by amidomethylation
Bilcik, Filip,Drusan, Michal,Marak, Jozef,Sebesta, Radovan
, p. 760 - 765 (2012)
Enantioselective conjugate addition of Grignard reagents to enones, catalyzed by Cu-Taniaphos or Josiphos complex, affords chiral enolates. Ensuing one-pot Mannich reaction with TiCl4-generated imine leads to aminocarbonyl compounds with benzyloxycarbonyl-protected nitrogen. Both diastereomers of these compounds are isolated in moderate yields but high enantiomeric purities (up to er 97.5:2.5).
