4548-78-1

Usage

Uses

Isoamylmagnesium Bromide is a reagent in the synthesis of Perilla Ketone (P287050), an oil from Perilla frutescens which is very toxic as it is a potent pulmonary edemagenic agent for laboratory animals and livestock. Isopentylmagnesium bromide solution 2 in diethyl ether is commonly used in oriental foods.

Upstream product

• 107-82-4 i-pentyl bromide 
• 7439-95-4 magnesium 
• 102803-57-6 3-methylbutylzinc chloride 
• 16696-65-4 1,11-dibromoundecane 
• 3344-70-5 1,12-dibromododecane 

Downstream Products

• 627-98-5 5-methyl-1-hexanol 
• 859948-86-0 diisopentyl-phenyl-carbinol 
• 107-85-7 1-amino-3-methylbutane 
• 19780-96-2 2,8-Dimethyl-5-hydroxynonane 
• 626-89-1 4-Methyl-1-pentanol 
• 464-72-2 tetraphenylethane-1,2-diol 
• 62016-38-0 2,4,7-trimethyloctane 
• 861323-10-6 isopentyl-benzhydryl-carbinol 
• 111528-89-3 3-cyclohexyl-6-methyl-1-piperidino-heptan-3-ol 
• 33978-71-1 2-Methyl-5-undecanol 
• 123-92-2 3-methyl-1-butyl acetate 
• 17312-50-4 2,5-Dimethyl-decan 
• 101082-33-1 5-(2-dimethylamino-ethyl)-2,8-dimethyl-nonan-5-ol 
• 107245-26-1 1-(dimethylamino)-6-methyl-3-heptanone 

Relevant academic research and scientific papers

Nickel-Catalyzed Cross-Coupling of Functionalized Organo manganese Reagents with Aryl and Heteroaryl Halides Promoted by 4-Fluorostyrene

A catalytic system consisting of Ni(acac) 2 (5 mol%) and 4-fluorostyrene (20 mol%) allows a convenient cross-coupling of functionalized organomanganese reagents with a variety of aryl and heteroaryl halides leading to polyfunctionalized diaryl- and arylheteroarylmethane derivatives.

IMPROVEMENTS IN OR RELATING TO ORGANIC COMPOUNDS

An aryl-substituted alkanal compound having a molecular weight of less than 300 g/mol and which bears a substituent on the aryl ring ortho to a substituent bearing the aldehyde functionality. Said compounds are useful as perfume ingredients in personal ca

GSM INTERMEDIATES

The present invention relates the use of compounds having the general Formula I, wherein the definitions or R1 and R2 are provided in the specification. Said compounds of Formula I are useful for the synthesis of a variety of g-secretase modulators, which are in turn useful for the treatment of diseases associated with y-secretase activity, including Alzheimer′s disease.

AMINE LINKED MODULATORS OF y-SECRETASE

The present invention relates to compounds of Formula I as shown below, wherein the definitions of A, X, Y, R1 R2, R3, R4, R5, R6, R7, R8, and R9 are provided in the specification. Compounds of Formula I are useful for the treatment of diseases associated with γ-secretase activity, including Alzheimer's disease.

METABOLICALLY STABLE ALKOXYALKYL ESTERS OF ANTIVIRAL OR ANTIPROLIFERATIVE PHOSPHONATES, NUCLEOSIDE PHOSPHONATES AND NUCLEOSIDE PHOSPHATES

The present invention relates to phosphonate, nucleoside phosphonate or nucleoside phosphate compounds, compositions containing them, processes for obtaining them, and their use in treating a variety of medical disorders, in particular viral infections, cancers and the like.

Compositions useful as inhibitors of protein kinases

The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides processes for preparing the compounds, pharmaceutically acceptable compositions comprising the compounds, and methods of using the compounds and compositions in the treatment of various disease, conditions, or disorders.

An ESR and HPLC-EC assay for the detection of alkyl radicals

The correlation of lipid peroxidation with release of alkanes (RH) is considered a noninvasive method for the in vivo evaluation of oxidative stress. The formation of RH is believed to reflect a lipid hydroperoxide (LOOH)-dependent generation of alkoxyl radicals (LO·) that undergo β-scission with release of alkyl radicals (R·). Alternatively, R· could be spin-trapped with a nitrone before the formation of RH and analyzed by ESR. Extracts from the liver and lung of CCl4- and asbestos-treated rats that were previously loaded with nitrones exhibited ESR spectra suggesting the formation of iso-propyl, n-butyl, ethyl, and pentyl radical-derived nitroxides. In biological systems, various nitroxides with indistinguishable ESR spectra could be formed. Hence, experiments with N-tert-butyl-α-phenylnitrone (PBN) for spin trapping of R· were carried out in which the nitroxides formed were separated and analyzed by HPLC with electrochemical detection (EC). The C1-5 homologous series of PBN nitroxides and hydroxylamines were synthesized, characterized by ESR, GC-MS, and HPLC-EC, and used as HPLC standards. For in vivo generation and spin trapping of R·, rats were loaded with CCl4 and PBN. The HPLC-EC chromatograms of liver extracts from CCl4-treated rats demonstrated the formation of both the nitroxide and hydroxylamine forms of PBN/·CCl3, as well as the formation of a series of unidentified PBN nitroxides and hydroxylamines. However, formation of PBN adducts with retention times similar to these of the PBN/C2-5 derivatives was not observed. In conclusion, we could not correlate the production of PBN-detectable alkyl radicals with the reported CCl4-dependent production of C1-5 alkanes. We speculate that the major reason for this is the low steady-state concentrations of R· produced because only a small fraction of LO· undergo β-scission to release R·.

Prostaglandin endoperoxide H synthase biosynthesis inhibitors

The present invention describes pyridazinone compounds of formula I which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX-2). COX-2 is the inducible isoform associated with inflammation, as opposed to the constitutive isoform, cyclooxygenase-1 (COX-1) which is an important “housekeeping” enzyme in many tissues, including the gastrointestinal (GI) tract and the kidneys. The selectivity of these compounds for COX-2 minimizes the unwanted GI and renal side-effects seen with currently marketed non-steroidal anti-inflammatory drugs (NSAIDs).

New syntheses of the rice moth and stink bug pheromones by employing (2R, 6S)-7-acetoxy-2,6-dimethyl-1-heptanol as a building block

(2R, 6R, 10R)-6,10,14-Trimethyl-2-pentadecanol, the female pheromone of the rice moth (Corcyra cephalonica), and methyl (2R, 6R, 10R)-2,6,10-trimethyltridecanoate, the male pheromone of the stink bug (Euschistus heros) were synthesized by employing (2R, 6S)-7-acetoxy-2,6-dimethyl-1-heptanol as the common chiral building block.

1,2-Induction in intramolecular diene cyclozirconation: Control of relative configuration

We have observed that cyclozirconation of a diene having a substituent on the bridge connecting the two alkene leads to a single predominant zirconacycle with control of three new stereogenic centers.