1351835-47-6

Basic information

• Product Name: 2-amino-2-(4-(4-butylbenzyl)phenethyl)propane-1,3-diol
• Synonyms: 2-amino-2-(4-(4-butylbenzyl)phenethyl)propane-1,3-diol
• CAS NO: 1351835-47-6
• Molecular Weight: 341.494
• Mol File: 1351835-47-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-amino-2-(4-(4-butylbenzyl)phenethyl)propane-1,3-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-2-(4-(4-butylbenzyl)phenethyl)propane-1,3-diol(1351835-47-6)
• EPA Substance Registry System: 2-amino-2-(4-(4-butylbenzyl)phenethyl)propane-1,3-diol(1351835-47-6)

Safety Data

• Hazardous Substances Data: 1351835-47-6(Hazardous Substances Data)

Upstream product

• 2767-70-6 (p-nitrobenzyl)triphenylphosphonium bromide 
• 1427308-40-4 C₁₉H₂₆N₂O₆ 
• 1427308-41-5 tert-butyl 5-(4-aminophenethyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate 
• 1427308-22-2 tert-butyl 2,2-dimethyl-5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenethyl)-1,3-dioxan-5-ylcarbamate 
• 1427308-27-7 tert-butyl 2,2-dimethyl-5-(4-(4-butylbenzyl)phenethyl)-1,3-dioxan-5-ylcarbamate 

Relevant articles and documents

Suzuki coupling based synthesis and in vitro cytotoxic evaluation of Fingolimod and analogues

A concise synthesis of Fingolimod (FTY720) and its analogues was described. The key step involved Suzuki coupling of arylboronate 11 with different bromides. In addition, the newly synthesized Fingolimod analogues (5a-i and 6a-c) were evaluated for their in vitro cytotoxicity against SMCC-7721 and HL-60 cell lines. The preliminary SAR was discussed.