1427308-27-7

Basic information

• Product Name: tert-butyl 2,2-dimethyl-5-(4-(4-butylbenzyl)phenethyl)-1,3-dioxan-5-ylcarbamate
• Synonyms: tert-butyl 2,2-dimethyl-5-(4-(4-butylbenzyl)phenethyl)-1,3-dioxan-5-ylcarbamate
• CAS NO: 1427308-27-7
• Molecular Weight: 481.676
• Mol File: 1427308-27-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl 2,2-dimethyl-5-(4-(4-butylbenzyl)phenethyl)-1,3-dioxan-5-ylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2,2-dimethyl-5-(4-(4-butylbenzyl)phenethyl)-1,3-dioxan-5-ylcarbamate(1427308-27-7)
• EPA Substance Registry System: tert-butyl 2,2-dimethyl-5-(4-(4-butylbenzyl)phenethyl)-1,3-dioxan-5-ylcarbamate(1427308-27-7)

Safety Data

• Hazardous Substances Data: 1427308-27-7(Hazardous Substances Data)

Upstream product

• 1427308-22-2 tert-butyl 2,2-dimethyl-5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenethyl)-1,3-dioxan-5-ylcarbamate 
• 10531-16-5 p-butylbenzylbromide 
• 1427308-41-5 tert-butyl 5-(4-aminophenethyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate 
• 1427308-40-4 C₁₉H₂₆N₂O₆ 
• 364631-73-2 tert-butyl 5-formyl-2,2-dimethyl-1,3-dioxan-5-ylcarbamate 

Downstream Products

• 1351835-47-6 2-amino-2-(4-(4-butylbenzyl)phenethyl)propane-1,3-diol 

Relevant articles and documents

Suzuki coupling based synthesis and in vitro cytotoxic evaluation of Fingolimod and analogues

A concise synthesis of Fingolimod (FTY720) and its analogues was described. The key step involved Suzuki coupling of arylboronate 11 with different bromides. In addition, the newly synthesized Fingolimod analogues (5a-i and 6a-c) were evaluated for their in vitro cytotoxicity against SMCC-7721 and HL-60 cell lines. The preliminary SAR was discussed.