1351932-48-3Relevant articles and documents
A practical one-pot radical-ionic sequence for the preparation of epoxides: Application to the synthesis of unnatural polyhydroxylated alkaloids
Peralta-Hernández, Eduardo,Cortezano-Arellano, Omar,Cordero-Vargas, Alejandro
, p. 6899 - 6902 (2011)
An efficient one-pot sequence for the preparation of epoxides from α-iodoesters or α-iodonitriles and allylic alcohols is described. This sequence is based on the use of iodine atom transfer reaction onto allylic alcohols followed by a ring closing epoxidation reaction of the halohydrin intermediates. The feasibility of this sequence is showcased in the synthesis of the perhydroaza-azulene, an unnatural analog of castanospermine.