1351945-09-9

Basic information

• Product Name: 7-(hydroxymethyl)-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide
• CAS NO: 1351945-09-9
• Molecular Weight: 452.433
• Mol File: 1351945-09-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-(hydroxymethyl)-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(hydroxymethyl)-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide(1351945-09-9)
• EPA Substance Registry System: 7-(hydroxymethyl)-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide(1351945-09-9)

Safety Data

• Hazardous Substances Data: 1351945-09-9(Hazardous Substances Data)

Upstream product

• 100202-39-9 methyl 3-azetidinecarboxylate hydrochloride 
• 1351945-34-0 7-formyl-1-methyl-4-oxo-N-(2-(trifluoromethyl)biphenyl-4-yl)-1,4-dihydroquinoline-3-carboxamide 
• 1255785-59-1 7-bromo-1-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 1351945-32-8 7-bromo-1-methyl-4-oxo-N-(2-(trifluoromethyl)-4-biphenylyl)-1,4-dihydro-3-quinolinecarboxamide 
• 1351945-33-9 1-methyl-4-oxo-N-(2-(trifluoromethyl)biphenyl-4-yl)-7-vinyl-1,4-dihydroquinoline-3-carboxamide 
• 591-19-5 m-Bromoaniline 
• 208580-23-8 7-bromo-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester 

Relevant articles and documents

Optimization of a potent, orally active S1P1 agonist containing a quinolinone core

The optimization of a series of S1P1 agonists with limited activity against S1P3 is reported. A polar headgroup was used to improve the physicochemical and pharmacokinetic parameters of lead quinolinone 6. When dosed orally at 1 and 3 mg/kg, the azahydroxymethyl analogue 22 achieved statistically significant lowering of circulating blood lymphocytes 24 h postdose. In rats, a dose-proportional increase in exposure was measured when 22 was dosed orally at 2 and 100 mg/kg.