135197-63-6

Basic information

• Product Name: 3'-Deoxy-3'-fluoro-5'-O-trityl-D-thymidine
• Synonyms: 3'-Deoxy-3'-fluoro-5'-O-trityl-D-thymidine;3'-Deoxy-3'-fluoro-5'-O-tritylthymidine;3'-Deoxy-3'-fluoro-5'-O-(triphenylMethyl)thyMidine
• CAS NO: 135197-63-6
• Molecular Formula: C₂₉H₂₇FN₂O₄
• Molecular Weight: 486.54
• Product Categories: Aromatics;Bases & Related Reagents;Heterocycles;Nucleotides
• Mol File: 135197-63-6.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3'-Deoxy-3'-fluoro-5'-O-trityl-D-thymidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-Deoxy-3'-fluoro-5'-O-trityl-D-thymidine(135197-63-6)
• EPA Substance Registry System: 3'-Deoxy-3'-fluoro-5'-O-trityl-D-thymidine(135197-63-6)

Safety Data

• Hazardous Substances Data: 135197-63-6(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

An intermediate in the preparation of thymidine monophosphate analogues

Upstream product

• 25442-42-6 5'-O-trityl-2,3'-anhydrothymidine 
• 50-89-5 thymidine 
• 141690-73-5 3'-Tosyl-5'-O-trityl thymidine 
• 76-83-5 trityl chloride 
• 7791-71-1 5'-O-tritylthymidine 
• 42214-24-4 1-(2-deoxy-3-O-methanesulfonyl-5-O-trityl-β-D-ribopentofuranosyl)thymine 
• 16053-52-4 threothymidine 
• 101527-40-6 5'-O-tert-butyldiphenylsilylthymidine 
• 139212-95-6 5'-O-tert-butyldiphenylsilyl-3'-O-methanesulfonylthymidine 
• 55612-11-8 5'-O-trityldeoxyxylothymidine 
• 104218-44-2 1-(2-deoxy-3-O-methanesulfonyl-5-O-trityl-β-D-threo-pentofuranosyl)thymine 

Downstream Products

• 25526-93-6 alovudine 
• 116195-70-1 3'-fluoro-5'-O-tert-butyldiphenylsilyl-3'-deoxythymidine 
• 136681-22-6 5-bromomethyl-1-[5-(tert-butyl-diphenyl-silanyloxymethyl)-4-fluoro-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione 
• 699007-45-9 5-(2,2,2-trifluoroethoxy)methyl-3'-fluoro-5'-O-tert-butyldiphenylsilyl-2',3'-dideoxyuridine 
• 699007-47-1 5-[bis(2,2,2-trifluoroethoxy)methyl]-3'-fluoro-5'-O-tert-butyldiphenylsilyl-2',3'-dideoxyuridine 
• 25520-83-6 phosphoric acid mono[3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)tetrahyrofuran-2-ylmethyl] ester 

Relevant articles and documents

Hydrofluorination of anhydrothymidine via soluble aluminum derivatives

A new method to stereospecifically hydrofluorinate anhydrothymidine has been discovered which allows the product to be obtained in higher yields than the current literature method.

Synthesis and evaluation of thymidine-5′-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase

A number of 2′- and 3′-modified thymidine 5′-O-monophosphate analogues were synthesized as potential leads for new anti-mycobacterial drugs. Evaluation of their affinity for Mycobacterium tuberculosis thymidine monophosphate kinase showed that a 2′-halogeno substituent and a 3′-azido function are the most favorable leads for further development of potent inhibitors of this enzyme.