1351982-02-9Relevant academic research and scientific papers
PREPARATION OF 2-METHYL-4-AMINO-5(SUBSTITUTED-1H-1,2,3-TRIAZOLYL)METHYLPYRIMIDINE DERIVATIVES AND MICROBICIDAL ACTIVITY THEREOF
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Paragraph 0031-0037; 0107-0113, (2014/07/22)
Disclosed is a derivative of 2-methyl-4-amino-5-(substituted-1H-1,2,3-triazol)methylpyrimidine of general formula I and microbicidal activity thereof. In the formula, R1 represents hydrogen, I; X represents O or NH; Y represents phenyl of substituted phen
Structure-based rational design of novel hit compounds for pyruvate dehydrogenase multienzyme complex E1 components from Escherichia coli
Ren, Yanliang,He, Junbo,Feng, Lingling,Liao, Xun,Jin, Jing,Li, Yongjian,Cao, Yi,Wan, Jian,He, Hongwu
experimental part, p. 7501 - 7506 (2012/01/03)
Pyruvate dehydrogenase multienzyme complex (PDHc) E1 component plays a pivotal role in cellular metabolism to convert the product of glycolysis (pyruvate) to acetyl-CoA, and has been reported as a potential target for anti-microbial and herbicide. In pres
