1352010-16-2Relevant academic research and scientific papers
Oxidative alkynylation of imines with alkynylcopper reagents: A straightforward and practical entry to ynimines
Laouiti, Anouar,Jouvin, Kvin,Bourdreux, Flavien,Rammah, Mohamedm.,Rammah, Mohamedb.,Evano, Gwilherm
experimental part, p. 1491 - 1500 (2012/06/16)
We have developed an efficient and general synthesis of ynimines based on an oxidative cross-coupling between imines and alkynylcopper reagents. Upon simple addition of 1,2-dimethylimidazole in the presence of oxygen, these bench-stable, crystalline, and readily available polymeric compounds were found to be especially suitable reagents for the introduction of an alkynyl group into a wide range of ketimines at room temperature and under especially mild conditions.
