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1352067-76-5

2-((3R,5S,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-((S)-1-(pyridin-2-yl)propyl)piperidin-3-yl)acetic acid is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

1352067-76-5

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  • 2-((3R,5S,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-((S)-1-(pyridin-2-yl)propyl)piperidin-3-yl)acetic acid

    Cas No: 1352067-76-5

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1352067-76-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1352067-76-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,5,2,0,6 and 7 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1352067-76:
(9*1)+(8*3)+(7*5)+(6*2)+(5*0)+(4*6)+(3*7)+(2*7)+(1*6)=145
145 % 10 = 5
So 1352067-76-5 is a valid CAS Registry Number.

1352067-76-5Downstream Products

1352067-76-5Relevant articles and documents

Discovery of potent and simplified piperidinone-based inhibitors of the MDM2-p53 interaction

Yu, Ming,Wang, Yingcai,Zhu, Jiang,Bartberger, Michael D.,Canon, Jude,Chen, Ada,Chow, David,Eksterowicz, John,Fox, Brian,Fu, Jiasheng,Gribble, Michael,Huang, Xin,Li, Zhihong,Liu, Jiwen,Lo, Mei-Chu,McMinn, Dustin,Oliner, Jonathan D.,Osgood, Tao,Rew, Yosup,Saiki, Anne Y.,Shaffer, Paul,Yan, Xuelei,Ye, Qiuping,Yu, Dongyin,Zhao, Xiaoning,Zhou, Jing,Olson, Steven H.,Medina, Julio C.,Sun, Daqing

, p. 894 - 899 (2014/09/17)

Continued optimization of the N-substituent in the piperidinone series provided potent piperidinone-pyridine inhibitors 6, 7, 14, and 15 with improved pharmacokinetic properties in rats. Reducing structure complexity of the N-alkyl substituent led to the discovery of 23, a potent and simplified inhibitor of MDM2. Compound 23 exhibits excellent pharmacokinetic properties and substantial in vivo antitumor activity in the SJSA-1 osteosarcoma xenograft mouse model.

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