1352085-98-3

Upstream product

• 1071-73-4 5-Hydroxy-2-pentanone 
• 31636-92-7 4-carbonylpentyl benzoate 
• 98-88-4 benzoyl chloride 

Downstream Products

• 647005-60-5 2-(2-(4-tert-butylphenyl)-5-methyloxazol-4-yl)ethanol 
• 477541-32-5 methanesulfonic acid 2-(5-methyl-2-p-tolyloxazol-4-yl)ethyl ester 
• 477541-38-1 2-[5-methyl-2-(4-nitrophenyl)oxazol-4-yl]ethyl methanesulfonate 
• 477541-29-0 2-[2-(4-tert-butylphenyl)-5-methyloxazol-4-yl]ethyl methanesulfonate 
• 1383439-70-0 C₁₄H₁₅N₅O₄S 
• 1383439-80-2 methyl 3-(2-ethyl-4-{2-[2-(4-fluorophenyl)-5-methyloxazol-4-yl]ethoxy}phenyl)propanoate 
• 1383439-81-3 C₂₅H₂₉NO₄ 
• 1383439-83-5 C₂₄H₂₆N₂O₆ 
• 1383439-85-7 C₂₈H₃₅NO₄ 
• 1383439-86-8 C₂₅H₂₇N₅O₄ 
• 1352085-87-0 3-(2-ethyl-4-{2-[2-(4-fluorophenyl)-5-methyloxazol-4-yl]ethoxyl}phenyl)propionic acid 
• 1352085-99-4 3-azido-4-carbonylpentyl benzoate 
• 1352086-01-1 3-amine-4-carbonylpentyl benzoate 
• 1352086-00-0 3-(4-fluorobenzamido)-4-carbonylpentyl benzoate 

Relevant academic research and scientific papers

COMPOUNDS HAVING ACTIVATING EFFECT ON SUBTYPES OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS AND ITS PREPARATION METHOD AND USES

Phenyl propanoic acid compounds having activating effect on peroxisome proliferator-activated receptors (PPARα,δ,γ) and a preparation method and uses thereof are provided in the present invention. The compounds can be used for treating or preventing diseases associated with peroxisome proliferator-activated receptors (PPARα,δ,γ).

Compounds Having Activating Effect on Subtypes of Peroxisome Proliferator-Activated Receptors and its Preparation Method and Uses

Phenyl propanoic acid compounds having activating effect on peroxisome proliferator-activated receptors (PPARα,δ,γ) and a preparation method and uses thereof are provided in the present invention. The compounds can be used for treating or preventing diseases associated with peroxisome proliferator-activated receptors (PPARα,δ,γ).

Design and synthesis of 3-(2-ethyl-4-{2-[2-(4-fluorophenyl)- 5-methyloxazol-4-yl]ethoxy}phenyl)propanoic acid: A novel triple-acting PPARα, -γ, and -δ Agonist

The design and synthesis of triple-acting PPARα, -γ, and -δ agonist 3-(2-ethyl-4-{2-[2-(4-fluorophenyl)-5-methyloxazol-4-yl]- ethoxy}phenyl)propanoic acid (1a) is described. The compound possesses a potent triple-acting PPARα, -γ, and -δ agonist profile with an EC50 of 0.029, 0.013, and 0.029 μM, respectively. The synthetic route, involving the synthesis of oxazole rings as the key step, starts from commercially available 3-oxopentanoic acid methyl ester and 3- hydroxyacetophenone to afford the target compound 1 with an overall yield of 32%.