1352134-72-5Relevant academic research and scientific papers
Zwitterionic liquid crystalline polythiophene as an antibiofouling biomaterial
Xu, Jinjia,Xu, Jian,Moon, Haesoo,Sintim, Herman O.,Lee, Hyowon
, p. 349 - 356 (2021)
To address a key challenge of conjugated polymers in biomedical applications having poor antifouling properties that eventually leads to the failure and reduced lifetime of bioelectronics in the body, herein we describe the design, synthesis, and evaluation of our newly designed multifunctional zwitterionic liquid crystalline polymer PCBTh-C8C10, which is facilely synthesized using oxidative polymerization. A conjugated polythiophene backbone, a multifunctional zwitterionic side chain, and a mesogenic unit are integrated into one segment. By DSC and POM characterization, we verify that the introduction of 3,5-bis(2-octyl-1-dodecyloxy)benzene as a mesogenic unit into the polythiophene backbone allows the formation of the liquid crystalline mesophase of the resulting polymer. We also demonstrate that the PCBTh-C8C10 coated surface exhibits good conductivity, stability, hydrophilicity, and remarkable antibiofouling properties against protein adsorption, cell growth, and bacteria attachment. This new zwitterionic liquid crystalline polymer having good antibiofouling features will be widely recognized as a promising biomaterial that is applicable in implantable organic bioelectronics via inhibiting the foreign body response. A deep understanding of structure-property relationships of zwitterionic conjugated polymers has also been provided in this study.
Preparation method of terra
-
Paragraph 0067-0069, (2021/10/05)
The invention provides a preparation method of terra, and relates to the technical field of chemical synthesis. The preparation method comprises the following steps: (a) reacting compound 1 with halogenated oxirane through Suzuki to obtain compound 2. (b) Compound 2 was reacted with tert-butylamine to yield terbutaline. Suzuki Reaction is creatively applied to preparation of terbutaline, the reaction steps are greatly shortened, the processes of protecting groups and deprotection are avoided by using the bromination reaction, the reaction conditions are mild, the reaction process is easy to control, and the safety coefficient is high. Raw materials are simple and easy to obtain, and the industrial cost is saved. The product yield is high. The purity is high, and the process route of a product with higher quality can be industrially produced.
A protecting group-free divergent synthesis of natural benzofurans via one-pot synthesis of 2-bromo-6-hydroxybenzofurans
Sivaraman, Aneesh,Harmalkar, Dipesh S.,Kang, Jiyoon,Choi, Yongseok,Lee, Kyeong
, p. 2153 - 2161 (2019/02/27)
2-Bromo-6-hydroxybenzofurans are potentially versatile intermediates for the divergent synthesis of numerous benzofuran-based natural products and their analogues. Herein we report the first one-pot strategy for the efficient synthesis of 2-bromo-6-hydrox
Cyclopropylmethyl Protection of Phenols: Total Synthesis of the Resveratrol Dimers Anigopreissin A and Resveratrol–Piceatannol Hybrid
Kumar, Arvind,Saleeb, Michael,Werz, Dominik,Elofsson, Mikael
, p. 953 - 956 (2018/11/23)
We demonstrate the versatile use of the cyclopropylmethyl group to protect phenols through the total synthesis of two benzofuran-based natural products, that is, anigopreissin A and the resveratrol–piceatannol hybrid. This protecting group is a good alter
