135219-45-3

Upstream product

• 501-53-1 benzyl chloroformate 
• 13518-40-6 L-valine tert-butylester hydrochloride 
• 3182-93-2 (L)-phenylalanine ethyl ester hydrochloride 
• 28709-70-8 N-benzyloxycarbonyl-L-phenylalanine ethyl ester 
• 1161-13-3 N-Cbz-L-Phe 
• 135219-73-7 (S)-2-{(R)-2-[3-((S)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-2-hydroxy-pentanoylamino]-4-methyl-pentanoylamino}-3-methyl-butyric acid tert-butyl ester 
• 135219-72-6 (S)-2-((R)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-3-methyl-butyric acid tert-butyl ester 

Relevant academic research and scientific papers

Poststatin, a new inhibitor of prolyl endopeptidase. V. Endopeptidase inhibitory activity of poststatin analogues

Thirty analogues of poststatin were synthesized, and their inhibitory activities against prolyl endopeptidase, human leukocyte elastase and cathepsin B were measured. The α-ketone was essential and the S configuration was preferable to the R configuration in the β-substituted-β-amino-α-oxopropionic acid moiety of poststatin analogues for endopeptidase inhibitory activity. The analogue in which the D-leucine residue of poststatin was replaced by L-leucine showed strong inhibitory activity to cathepsin B. Introduction of an aromatic group into the P4 position and proline into the P2 position increased inhibitory activity to elastase. Benzyloxycarbonyl-L-homophenylalanyl-(RS)-3-amino-2-oxovaleryl-D- leucyl-L-valine was about 6 times more active to prolyl endopeptidase than natural poststatin.