1352211-97-2

Upstream product

• 21090-30-2 3'-O-acetylthymidine 
• 872298-31-2 2-(N-benzyl-pyridin-2-yl-amino)ethanol 
• 1053653-67-0 3'-O-acetylthymidine 5'-O-(1-imidazolyl)carbamate 
• 89943-04-4 2-(pyridin-2-ylamino)ethanol 
• 104-63-2 N-Benzylethanolamine 
• 1352211-89-2 C₁₈H₁₈N₄O₂ 
• 109-04-6 2-bromo-pyridine 

Downstream Products

• 21090-30-2 3'-O-acetylthymidine 

Relevant academic research and scientific papers

Novel thermolabile protecting groups with higher stability at ambient temperature

Novel thermolabile hydroxyl protecting groups of increased thermostability are proposed. The stability of these groups at different temperatures ranges has been determined. The 2-pyridyl-N-(2,4-difluorobenzyl)aminoethyl unit was selected as stable at ambient temperature and very labile at increased temperature. The half-life times for the best groups were established. Application of this chemistry to the protection of different hydroxyl groups of thymidine was also demonstrated.

THERMOLABILE 2 - (N- 2 - PYRIDIYL - N- BENZYL) - AMINOETHYLOXYCARBONYL DERIVATIVES AS HYDROXYL FUNCTION PROTECTING AGENTS

The subject of the invention is a new way of using thermolabile groups to protect a hydroxyl function, above all in nucleosides, nucleotides, oligomers, nucleic acids during the reactions of organic synthesis. The invention also covers new compounds that