1352212-86-2

Upstream product

• 401564-17-8 (2S,4S)-1-(tert-butoxycarbonyl)-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-2-carboxylic acid 
• 1352212-85-1 (2S,4S)-tert-butyl 4-(tert-butyldimethylsilyloxy)-2-(phenylcarbamoyl)pyrrolidine-1-carboxylate 
• 74-88-4 methyl iodide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 74844-91-0 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate 
• 13726-69-7 (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid 
• 74844-91-0 (2S,4S)-N-tert-butoxycarbonyl-4-hydroxyproline methyl ester 
• 51-35-4 4R-4-hydroxyproline 
• 188109-82-2 (2S,4S)-1-tert-butyl 2-methyl 4-acetoxypyrrolidine-1,2-dicarboxylate 
• 367966-45-8 (2S,4S)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1,2-pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) 2-methyl ester 

Downstream Products

• 1352212-87-3 (2S,4S)-1-(3-(allyloxy)-2-iodobenzyl)-4-(tert-butyldimethylsilyloxy)-N-methyl-N-phenyl-pyrrolidine-2-carboxamide 
• 1352212-89-5 (2S,10S,10aS)-9-allyloxy-10-benzoyloxy-2-hydroxy-1,2,3,5,10,10a-hexahydropyrrolo[1,2-b]isoquinoline 
• 1352212-94-2 (2S,10S,10aS)-9-allyloxy-10-benzoyloxy-1,2,3,5,10,10a-hexahydropyrrolo[1,2-b]isoquinolin-2-yl (2'R,3'S)-3'-benzoylamino-2'-hydroxy-3'-(2-(allyloxy)phenyl)-propanoate 
• 1352212-93-1 (2S,10S,10aS)-9-allyloxy-10-benzoyloxy-1,2,3,5,10,10a-hexahydropyrrolo[1,2-b]isoquinolin-2-yl (2'R,3'S)-3'-benzoylamino-2'-hydroxy-3'-(2-(but-3-enyloxy)phenyl)-propanoate 
• 1352212-95-3 (2S,10S,10aS)-9-allyloxy-10-benzoyloxy-1,2,3,5,10,10a-hexahydropyrrolo[1,2-b]isoquinolin-2-yl (2'R,3'S)-3'-benzoylamino-2'-hydroxy-3'-(2-allylphenyl)-propanoate 
• 1352212-96-4 (2S,10S,10aS)-9-allyloxy-10-hydroxy-1,2,3,5,10,10a-hexahydropyrrolo[1,2-b]isoquinolin-2-yl (2'R,3'S)-3'-benzoylamino-2'-triisopropylsilyloxy-3'-(2-(but-3-enyloxy)phenyl)-propanoate 
• 1352212-97-5 (2S,10S,10aS)-9-allyloxy-10-hydroxy-1,2,3,5,10,10a-hexahydropyrrolo[1,2-b]isoquinolin-2-yl (2'R,3'S)-3'-benzoylamino-2'-triisopropylsilyloxy-3'-(2-(allyloxy)phenyl)-propanoate 
• 1352212-98-6 (2S,10S,10aS)-9-allyloxy-10-hydroxy-1,2,3,5,10,10a-hexahydropyrrolo[1,2-b]isoquinolin-2-yl (2'R,3'S)-3'-benzoylamino-2'-triisopropylsilyloxy-3'-(2-allylphenyl)-propanoate 
• 1352212-99-7 (2S,10R,10aS)-9-allyloxy-10-hydroxy-1,2,3,5,10,10a-hexahydropyrrolo[1,2-b]isoquinolin-2-yl (2'R,3'S)-3'-benzoylamino-2'-triisopropylsilyloxy-3'-(2-allylphenyl)-propanoate 
• 1352213-08-1 (2S,10R,10aS)-9-allyloxy-10-benzoyloxy-1,2,3,5,10,10a-hexahydropyrrolo[1,2-b]isoquinolin-2-yl (2'R,3'S)-3'-benzoylamino-2'-triisopropylsilyloxy-3'-(2-allylphenyl)-propanoate 
• 1352213-09-2 (2S,10R,10aS)-9-allyloxy-10-benzoyloxy-1,2,3,5,10,10a-hexahydropyrrolo[1,2-b]isoquinolin-2-yl (2'R,3'S)-3'-benzoylamino-2'-hydroxy-3'-(2-allylphenyl)-propanoate 
• 1352213-10-5 C₅₀H₆₀N₂O₈Si 
• 1352213-11-6 C₅₁H₆₂N₂O₈Si 
• 1352213-12-7 C₅₀H₆₀N₂O₇Si 

Relevant academic research and scientific papers

Design and synthesis of simplified taxol analogs based on the T-Taxol bioactive conformation

A series of compounds designed to adopt a conformation similar to the tubulin-binding T-Taxol conformation of the anticancer drug paclitaxel has been synthesized. Both the internally bridged analogs 37-39, 41 and the open-chain analogs 27-29 and 43 were prepared. The bridged analogs 37-39 and 41 were synthesized by Grubbs' metatheses of compounds 30-32 and 33, which, in turn, were prepared by coupling β-lactams 24-26 with alcohols 22 and 23. Both the bridged and the open-chain analogs showed moderate to good cytotoxicity.