1352228-93-3

Basic information

• Product Name: C₂₀H₁₅BrClN₃O₂S
• Synonyms: C₂₀H₁₅BrClN₃O₂S
• CAS NO: 1352228-93-3
• Molecular Weight: 476.781
• Mol File: 1352228-93-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₁₅BrClN₃O₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₁₅BrClN₃O₂S(1352228-93-3)
• EPA Substance Registry System: C₂₀H₁₅BrClN₃O₂S(1352228-93-3)

Safety Data

• Hazardous Substances Data: 1352228-93-3(Hazardous Substances Data)

Upstream product

• 86169-24-6 2-amino-(2-chlorophenyl)ethanoic acid 
• 1188890-57-4 C₁₀H₉BrClNO₂ 
• 1352229-31-2 3-(2-chlorophenyl)pyrazine-2(1H)-thione 
• 3253-05-2 3-(2-chlorophenyl)pyrazin-2(1H)-one 
• 141109-17-3 (+/-)-2-chlorophenylglycine methyl ester hydrochloride 

Relevant articles and documents

Discovery of novel 2-(3-(2-chlorophenyl)pyrazin-2-ylthio)-N-arylacetamides as potent HIV-1 inhibitors using a structure-based bioisosterism approach

The present work is an extension of our ongoing efforts towards the development and identification of new molecules with anti-HIV activity which have previously led to the discovery of arylazolylthioacetanilides as highly active NNRTIs. In this article, a series of 2-2-(3-(2-chlorophenyl)pyrazin-2- ylthio)-N-arylacetamide derivatives were synthesized and evaluated for in vitro anti-HIV activity. Most of the tested compounds exhibited moderate activities against wild-type HIV-1. Among them, compound 6k showed significant activity against wild-type HIV-1 with an EC50 value of 1.7 μM, along with moderate activity against wild-type reverse transcriptase (RT). The preliminary structure-activity relationship (SAR) and docking calculations of this new series of compounds were also investigated, which may help designing more potent molecules.