1352240-29-9Relevant academic research and scientific papers
Discovery of selective glucocorticoid receptor modulator MK-5932
Bungard, Christopher J.,Hartman, George D.,Manikowski, Jesse J.,Perkins, James J.,Bai, Chang,Brandish, Philip E.,Euler, Danielle H.,Hershey, James C.,Schmidt, Azriel,Fang, Yulin,Norcross, Ryan T.,Rushmore, Tom H.,Thompson, Charles D.,Meissner, Robert S.
, p. 7374 - 7386 (2012/01/06)
A series of partial agonists of the Glucocorticoid Receptor were prepared targeting reduced transactivation activity, while maintaining significant transrepression activity. Incorporation of an ortho-aryl amide produced compounds with the desired in vitro
