1352297-89-2

Upstream product

• 1276118-43-4 2-([1,1'-biphenyl]-4-yl)-1,2,3,4-tetrahydroisoquinoline 
• 333-20-0 potassium thioacyanate 
• 613-90-1 benzoyl cyanide 

Relevant academic research and scientific papers

Oxidative cyanation of: N-aryltetrahydroisoquinoline induced by visible light for the synthesis of α-aminonitrile using potassium thiocyanate as a "cN" agent

A novel method for the synthesis of α-aminonitrile through visible-light-induced oxidative cyanation of N-aryltetrahydroisoquinoline with potassium thiocyanate has been developed. The process does not require the use of a photocatalyst, transition metal r

Method for preparing alpha-aminonitrile and product and application thereof

The invention discloses a method for preparing alpha-aminonitrile, which comprises the following steps: by using tertiary amine and benzoyl cyanide as reactants, carrying out visible light irradiationin an organic solvent under the condition of oxygen or

Electron Donor-Acceptor Complex-Initiated Photochemical Cyanation for the Preparation of α-Amino Nitriles

An electron donor-acceptor complex-initiated α-cyanation of tertiary amines has been described. The reaction protocol provides a novel method to synthesize various α-amino nitriles under mild conditions. The reaction can proceed smoothly without the presence of photocatalysts and transition metal catalysts, and either oxidants are unnecessary or O2 is the only oxidant. The practicality of this method is showcased not only by the late-stage functionalization of natural alkaloid derivatives and pharmaceutical intermediate, but also by the applicability of a stop-flow microtubing reactor.

Visible-light photoredox catalyzed oxidative Strecker reaction

An aerobic photocatalytic oxidative cyanation of tertiary amines providing valuable α-aminonitriles in good to excellent yields was developed. Mild reaction conditions and low catalyst loading are attractive features of the protocol. The Royal Society of