1352308-27-0

Upstream product

• 186641-79-2 (R)-4-((tert-Butyldiphenylsilyl)oxy)-3-methylbutanal 
• 128329-63-5 6-[[(tert-butyl)diphenylsilyl]oxy]-(3S,5R)-3,5-dimethyl-hexan-1-ol 
• 1351186-30-5 (3R,4R,6S)-8-((R)-N,2-dimethylbutanamido)-3,4,6-trimethyl-N-((R)-1-(tritylthio)but-3-en-2-yl)octanamide 
• 1351186-21-4 (R)-N-((3S,5R)-6-hydroxy-3,5-dimethylhexyl)-N,2-dimethylbutanamide 
• 1351186-29-2 (R)-N-((3S,5R)-6-(tert-butyldiphenylsilyloxy)-3,5-dimethylhexyl)-N,2-dimethylbutanamide 
• 1351186-20-3 (R)-N-((3S,5R)-6-(tert-butyldiphenylsilyloxy)-3,5-dimethylhexyl)-2-methylbutanamide 
• 1351186-26-9 ((2R,4S)-6-azido-2,4-dimethylhexyloxy)(tert-butyl)diphenylsilane 

Relevant academic research and scientific papers

Synthesis and biological activity of kalkitoxin and its analogues

Total syntheses of kalkitoxin, isolated from the Caribbean Lyngbya majuscula, and its analogues, 3-epi-, 7-epi-, 8-epi-, 10-epi-, 10-nor-, and 16-nor-kalkitoxin, were achieved via oxazolidinone-based diastereoselective 1,4-addition reaction of a methyl group and efficient TiCl4-mediated thiazoline ring formation as the key steps. The biological activities of synthetic kalkitoxin and its analogues were evaluated with brine shrimp.