128329-63-5

Upstream product

• 128329-62-4 (4R,1E)-4,6-dimethyl-7-((1,1-dimethylethenyl)diphenylsiloxy)-1-phenyl-1-heptene 
• 186641-79-2 (R)-4-((tert-Butyldiphenylsilyl)oxy)-3-methylbutanal 
• 123444-68-8 (S)-4-(tert-butyldiphenylsilyloxy)-3-methylbutanal 
• 1351186-13-4 (R)-3-((3S,5S)-6-(tert-butyldiphenylsilyloxy)-3,5-dimethylhexanoyl)-4-phenyloxazolidin-2-one 
• 104554-88-3 (2S,4'R,6'E)-1-(2',4'-dimethyl-7'-phenyl-6'-heptenoyl)-2-(hydroxymethyl)pyrrolidine 
• 104554-89-4 (4R,6E)-2,4-dimethyl-7-phenyl-6-heptenoic acid 
• 128329-61-3 (4R,6E)-2,4-dimethyl-7-phenyl-6-hepten-1-ol 
• 198124-61-7 (3R,4R,5R)-3,5-dimethyl-6-[tert-butyldiphenylsilyloxy]-hex-1-en-4-ol 
• 320742-72-1 (2S,4S)-2,4-dimethyl-1-(tert-butyldiphenylsilyloxy)-5-hexene 
• 129032-45-7 (2R,4S)-2,4-dimethyl-1-<(tert-butyldiphenylsilyl)oxy>hex-5-ene 
• 127793-69-5 (2S,4R)-5-{[tert-butyl(diphenyl)silyl]oxy}-2,4-dimethylpentanal 
• 321162-62-3 Toluene-4-sulfonic acid (1R,2R)-1-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2-methyl-but-3-enyl ester 

Downstream Products

• 1351186-26-9 ((2R,4S)-6-azido-2,4-dimethylhexyloxy)(tert-butyl)diphenylsilane 
• 1351186-20-3 (R)-N-((3S,5R)-6-(tert-butyldiphenylsilyloxy)-3,5-dimethylhexyl)-2-methylbutanamide 
• 1351186-29-2 (R)-N-((3S,5R)-6-(tert-butyldiphenylsilyloxy)-3,5-dimethylhexyl)-N,2-dimethylbutanamide 
• 1351186-30-5 (3R,4R,6S)-8-((R)-N,2-dimethylbutanamido)-3,4,6-trimethyl-N-((R)-1-(tritylthio)but-3-en-2-yl)octanamide 
• 1352308-27-0 (R)-N,2-dimethyl-N-((3S,5R,6R)-3,5,6-trimethyl-7-((R)-4-vinyl-4,5-dihydrothiazol-2-yl)heptyl)butanamide 
• 320742-74-3 Methanesulfonic acid (3S,5S)-6-(tert-butyl-diphenyl-silanyloxy)-3,5-dimethyl-hexyl ester 
• 320742-76-5 (3S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-3,5-dimethyl-hexylamine 
• 247184-89-0 (+)-kalkitoxin 
• 320742-77-6 (R)-N-((3S,5S)-6-(tert-butyldiphenylsilyloxy)-3,5-dimethylhexyl)-2-methylbutanamide 
• 320742-78-7 (2R)-N-methyl-N-[(3S,5S)-dimethyl-6-(tert-butyldiphenylsilyloxy)-hex-1-yl]-2-methylbutyramide 

Relevant academic research and scientific papers

Studies directed towards the total synthesis of polyether antibiotic ionomycin: Asymmetric synthesis of fragments C(24)-C(32) and C(1)-C(23)

A convergent and stereoselective approach for the synthesis of C1-C23 and C24-C32 segments of polyether antibiotic, ionomycin has been achieved. The key steps involved in this approach are the elaboration of two advanced fragments from a common precursor

Synthesis and biological activity of kalkitoxin and its analogues

Total syntheses of kalkitoxin, isolated from the Caribbean Lyngbya majuscula, and its analogues, 3-epi-, 7-epi-, 8-epi-, 10-epi-, 10-nor-, and 16-nor-kalkitoxin, were achieved via oxazolidinone-based diastereoselective 1,4-addition reaction of a methyl group and efficient TiCl4-mediated thiazoline ring formation as the key steps. The biological activities of synthetic kalkitoxin and its analogues were evaluated with brine shrimp.

An expeditious total synthesis of kalkitoxins: Determination of the absolute stereostructure of natural kalkitoxin

Kalkitoxin, a potent neurotoxin isolated from the marine cyanobacteria Lyngbya majuscula, and its congeners (1-7) were efficiently synthesized utilizing Hruby's diastereoselective 1,4-addition and the Wipf's oxazoline-thiazoline conversion as key steps. T

Stereoselective synthesis of syn- and anti-1,3- and 1,2-dimethyl arrays via asymmetric conjugate additions

Asymmetric conjugate additions have been investigated with enantiopure N-enoyloxazolidinones for efficient construction of syn and anti-1,3-dimethyl arrays on an acyclic carbon backbone. Reactions of Yamamoto organocopper species exhibit characteristics of double asymmetric induction resulting from influences of the 4-substituted chiral auxiliary and features of side chain stereochemistry.