1352308-72-5Relevant academic research and scientific papers
Enantioselective synthesis and antimicrobial activities of tetrahydro-β-carboline diketopiperazines
Ma, Yangmin,Wu, Hao,Zhang, Jin,Li, Yanchao
, p. 656 - 662 (2013/09/24)
A series of single isomers tetrahydro-β-carboline diketopiperazines were stereoselectively synthesized starting from l-tryptophan methyl ester hydrochloride and six aldehydes through a four-step reaction including Pictet-Spengler reaction, crystallization-induced asymmetric transformations (CIAT), Schotten-Baumann reaction, and intramolecular ester amidation. The chemical structures were characterized by nuclear magnetic resonance (NMR) and elemental analysis, among which two compounds were determined by x-ray single crystal diffraction. Moreover, antimicrobial activities of all the compounds were also tested. Chirality 25:656-662, 2013. 2013 Wiley Periodicals, Inc.
