1352308-80-5

Upstream product

• 1352308-77-0 (1S,3S)-methyl 1-(4-hydroxy-3-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride 
• 7524-52-9 (S)-tryptophan methyl ester hydrochloride 
• 73-22-3 L-Tryptophan 

Downstream Products

• 1352308-72-5 (5aS,12S,14aS)-12-(4-hydroxy-3-methoxyphenyl)-1,2,3,5a,6,14ahexahydropyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14(11H,12H)-dione 

Relevant academic research and scientific papers

Enantioselective synthesis and antimicrobial activities of tetrahydro-β-carboline diketopiperazines

A series of single isomers tetrahydro-β-carboline diketopiperazines were stereoselectively synthesized starting from l-tryptophan methyl ester hydrochloride and six aldehydes through a four-step reaction including Pictet-Spengler reaction, crystallization-induced asymmetric transformations (CIAT), Schotten-Baumann reaction, and intramolecular ester amidation. The chemical structures were characterized by nuclear magnetic resonance (NMR) and elemental analysis, among which two compounds were determined by x-ray single crystal diffraction. Moreover, antimicrobial activities of all the compounds were also tested. Chirality 25:656-662, 2013. 2013 Wiley Periodicals, Inc.