1352308-75-8Relevant academic research and scientific papers
Highly diastereoselective crystallization-induced asymmetric transformation of 1,3-disubstituted-tetrahydro-β-carbolines in water
Meng, Tian-Zhuo,Shi, Xiao-Xin,Qu, Hui-Ya,Zhang, Yi,Huang, Zhong-Shou,Fan, Qi-Qi
, p. 47753 - 47757 (2017/10/18)
A green and highly stereoselective method for the synthesis of cis or trans-1,3-disubstituted-tetrahydro-β-carbolines has been developed using water as the solvent. A mixture of cis and trans-1,3-disubstituted-tetrahydro-β-carboline hydrochlorides can be converted to a single cis or trans isomer via a crystallization-induced asymmetric transformation process. It is possible to get both isomers using this method by incorporating different additives in water. This method has advantages such as environmental friendliness, high stereoselectivity, suitability for industrialization, and non-toxicity.
Enantioselective synthesis and antimicrobial activities of tetrahydro-β-carboline diketopiperazines
Ma, Yangmin,Wu, Hao,Zhang, Jin,Li, Yanchao
, p. 656 - 662 (2013/09/24)
A series of single isomers tetrahydro-β-carboline diketopiperazines were stereoselectively synthesized starting from l-tryptophan methyl ester hydrochloride and six aldehydes through a four-step reaction including Pictet-Spengler reaction, crystallization-induced asymmetric transformations (CIAT), Schotten-Baumann reaction, and intramolecular ester amidation. The chemical structures were characterized by nuclear magnetic resonance (NMR) and elemental analysis, among which two compounds were determined by x-ray single crystal diffraction. Moreover, antimicrobial activities of all the compounds were also tested. Chirality 25:656-662, 2013. 2013 Wiley Periodicals, Inc.
