1352319-07-3Relevant articles and documents
Total synthesis of 3,5-O-dicaffeoylquinic acid and its derivatives
Raheem, K. Saki,Botting, Nigel P.,Williamson, Gary,Barron, Denis
, p. 7175 - 7177 (2012/01/05)
We report the first total synthesis of 3,5-O-dicaffeoylquinic acid and its derivatives, 3,5-O-diferuloylquinic acid and 3,5-(3,4-dimethoxycinnamyl)quinic acid, in a nine-step sequence. The key step involves Knoevenagel condensations between vanillin, 3,4-dimethoxybenzaldehyde or 4-hydroxy-3-methoxybenzaldehyde and the dimalonate ester of quinic acid.