1352346-92-9Relevant academic research and scientific papers
Enantioselective synthesis of azaflavanones using organocatalytic 6-endo aza-Michael addition
Cheng, Shuanghua,Zhao, Lili,Yu, Shouyun
, p. 982 - 986 (2014)
A method to prepare highly enantioenriched azaflavanones using an organocatalytic 6-endo aza-Michael addition has been described. A variety of 2-aryl-, 2-vinyl- and 2-methylazaflavanones were prepared in good yields (53-84%) and excellent enantioselectivities (97.6:2.4 to 99.3:0.7 er).
Azaisoflavones: Synthesis, antimicrobial evaluation and binding affinity with DNA gyrase
Praveen,Parthasarathy,Kumar, P. Senthil,Perumal
, p. 373 - 382 (2015/03/31)
Antimicrobial potency of azaisoflavones has been evaluated in vitro against nine bacterial and two fungal strains, respectively. The requisite azaisoflavones are conveniently synthesized in three steps, with the key step being the super acid catalyzed tandem reaction. The biological results reveal that out of twelve compounds screened, 3 compounds (5a, 5j and 5l) exhibited comparable activities against the standard drugs and demonstrated activities at μM concentration. In addition, molecular docking revealed that compound 5a as the most potent by showing a least binding energy of -5.99 kcal/mol with DNA gyrase receptor compared to other compounds.
Synthesis and cdc25B inhibitory activity evaluation of chalcones
Zhao, Fei,Zhao, Qing-Jie,Zhao, Jing-Xia,Zhang, Da-Zhi,Wu, Qiu-Ye,Jin, Yong-Sheng
, p. 206 - 214 (2013/07/26)
A library of sixty-five chalcones was prepared for screening against the protein phosphatase, cdc25B. From this library, thirteen compounds were found having good inhibitory activity. Two compounds have excellent activity and can be used for the design of
