135235-95-9Relevant academic research and scientific papers
SYNTHESIS OF 3-AMINO-4,4,4-TRIFLUORO-3-PHENYLBUTYRIC ACID
Kolycheva, M. T.,Gerus, I. I.,Yagupol'skii, Yu. L.,Kukhar', V. P.
, p. 101 - 104 (2007/10/02)
By the action of bis(trifluoroacetic) anhydride on 2,2,2-trifluoroacetophenone imine in the presence of pyridine the N-(trifluoroacetyl) derivative of the imine is formed, and this reacts with alkyl vinyl ethers and with ketene with the formation, respectively, of dihydro-1,3-oxazines and of a dihydro-1,3-oxazin-6(6H)-one.The latter is converted by hydrolysis with dilute and with concentrated acids into 3-phenyl-N-(trifluoroacetyl)-3-(trifluoromethyl)-β-alanine and the free acid.
