135245-99-7

Upstream product

• 1676-81-9 N-benzyloxycarbonyl-L-serine methyl ester 
• 117833-99-5 N-benzyloxycarbonyl 4(S)-(1'-methoxycarbonyl)-2,2-dimethyl-1,3-oxazolidine 
• 501-53-1 benzyl chloroformate 
• 128466-45-5 (R)-4-hydroxymethyl-2,2-dimethyloxazolidine-3-carboxylic acid benzyl ester 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 128466-46-6 benzyl (+)-(S)-2,2-dimethyl-4-(iodomethyl)oxazolidine-N-carboxylate 
• 176312-00-8 benzyl (4R)-4-(azidomethyl)-2,2-dimethyloxazolidine-3-carboxylate 
• 128466-37-5 (+)-(S)-O-(tert-butyldiphenylsilyl)-3-iodo-2-(benzyloxycarbonyl)aminopropan-1-ol 
• 128466-36-4 (+)-(S)-2-(benzyloxycarbonyl)amino-3-iodopropan-1-ol 

Relevant academic research and scientific papers

Enantiospecific synthesis of (R)- and (S)-2,3-diaminopropanol from L- and D-serine

Both chiral forms of 2,3-diaminopropanol (6) have been prepared in a convenient 5-step synthesis based on the readily available N-benzyloxycarbonyl derivatives of the methyl esters of L- and D-serine.

SYNTHESIS OF THE HOMOCHIRAL "TRICYCLIC HEART" OF MANZAMINE A

An expedient and enantiospecific synthesis of a strategically functionalized tricyclic intermediate for the construction of manzamine A is described.