135251-12-6Relevant articles and documents
Direct conversion of an ortho-allylphenol into a chlorosulfonyl-3-methyl-1, 2-benzoxathiin 2,2-dioxide
Qaisi, Ali M.,El-Abadelah, Mustafa M.,Voelter, Wolfgang
, p. 1059 - 1062 (2004)
A one-pot synthesis of methyl 6-chlorosulfonyl-3-methyl-1,2-benzoxathiin-8- carboxylate 2,2-dioxide (9), characterized as its 6-(4-methylpiperazin-1-yl) sulfonyl derivative 10, is achieved via direct reaction of methyl 3-allylsalicylate (1) with chlorosulfonic acid at -7°C. The latter reagent converts methyl 2-methyl-2,3-dihydrobenzofuran-7-carboxylate (3) into the respective 5-chlorosulfonyl derivative 7 (identified as its 5-(4- methylpiperazin-1-yl)sulfonyl derivative 8), while contrary to literature reports, the aromatic δ-sultones 9, 10 (anticipated to be produced from 3) were not detected.
