1776-08-5

Basic information

• Product Name: 2-Propen-1-one, 3-(dimethylamino)-1-(2-hydroxyphenyl)-
• Synonyms: 3-(dimethylamino)-1-(2-hydroxyphenyl)prop-2-en-1-one;3-(dimethylamino)-1-(2-hydroxyphenyl)-prop-2-en-1-one;1-(2-hydroxyphenyl)-3-(N,N-dimethylamino)propenone;1-(2-hydroxyphenyl)-3-N,N-dimethylaminoprop-2-ene-1-one;3-(dimethylamino)-1-(1-hydroxyphen-2-yl)prop-2-en-1-one;3-(dimethylamino)-1-(2-hydroxyphenyl)-2-propen-1-one
• CAS NO: 1776-08-5
• Molecular Formula: C11H13NO2
• Molecular Weight: 191.23
• Mol File: 1776-08-5.mol
• Article Data: 71

Chemical Properties

• Melting Point: 123 °C(Solv: xylene (1330-20-7))
• Boiling Point: 310.6±42.0 °C(Predicted)
• Density: 1.126±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-Propen-1-one, 3-(dimethylamino)-1-(2-hydroxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 3-(dimethylamino)-1-(2-hydroxyphenyl)-(1776-08-5)
• EPA Substance Registry System: 2-Propen-1-one, 3-(dimethylamino)-1-(2-hydroxyphenyl)-(1776-08-5)

Safety Data

• Hazardous Substances Data: 1776-08-5(Hazardous Substances Data)

Upstream product

• 118-93-4 o-hydroxyacetophenone 
• 68-12-2 N,N-dimethyl-formamide 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 39079-62-4 chromone-3-carboxylic acid 
• 124-40-3 dimethyl amine 
• 1776-09-6 3-bromochroman-4-one 
• 17422-74-1 3-Formylchromone 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 

Downstream Products

• 69-72-7 salicylic acid 
• 34810-67-8 2-(1H-pyrazol-3-yl)phenol 
• 49619-82-1 3-bromo-4H-chromen-4-one 
• 42059-73-4 (2E)-3-(4-oxo-4H-chromen-3-yl)-2-propenenitrile 
• 1260485-29-7 diethyl 2'-hydroxybenzophenone-3,5-dicarboxylate 
• 42059-71-2 (2E)-3-(4-oxo-4H-chromen-3-yl)acrylic acid ethyl ester 
• 1345865-42-0 2-[1-(4-chlorophenyl)-1H-pyrazol-5-yl]phenol 
• 491-38-3 1-benzopyran-4(4H)-one 
• 814257-04-0 2-[1-(pyridin-2-yl)-1H-pyrazol-3-yl]phenol 
• 814257-05-1 2-[1-(pyridin-2-yl)-1H-pyrazol-5-yl]phenol 
• 1384106-89-1 2-(2-chlorophenyl)-4-oxo-4H-chromene-3-carbonitrile 
• 1384106-90-4 2-(2-fluorophenyl)-4-oxo-4H-chromene-3-carbonitrile 
• 1384106-91-5 2-(4-fluoro-phenyl)-4-oxo-4H-chromene-3-carbonitrile 
• 1384106-92-6 4-oxo-2-o-tolyl-4H-chromene-3-carbonitrile 

Relevant articles and documents

1-Aryl-3-(dimethylamino)propenones: Strong proton acceptors for hydrogen bonds

Because of the electron-donating effects of their terminal dimethylamino groups, the carbonyl units of 1-aryl-3-(dimethylamino)prop-2-en-1-ones are excellent proton acceptors. Intra- and intermolecular hydrogen bonds formed by these species were investigated by structural techniques (X-ray and neutron diffraction), spectroscopy, and density functional calculations. Co-crystallization of a derivative bearing three (dimethylamino)prop-2-en-1-one units attached at one center in the presence of different proton donors produced one- and two-dimensional H-bridged polymers. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

Heterocyclic Systems; 10. Defunctionalisation of 4-Oxo-4H-benzopyran-3-carboxylic acids and -3-carboxaldehydes

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X-ray diffraction and VT-NMR studies of (E)-3-(piperidinyl)-1-(2′-hydroxyphenyl)-prop-2-en-1-one

A series of 1-aryl-3-(cyclicamino)-prop-2-en-1-one analogs was synthesized from commercial acetophenones in 2 or 3 steps. Compound 6, (E)-3-(piperidinyl)-1-(2′-hydroxyphenyl)-prop-2-en-1-one, exhibited the unique shape and intensity of the Csp2

Synthesis of 3,4,5-Trisubstituted Isoxazoles via the ANRORC Rearrangement

A facile and versatile procedure for the synthesis of new functionalized derivatives of 3-benzyl-5-(2-hydroxyphenyl) isoxazole-4-carbaldehyde oxime has been described. The key step in the synthesis involves the ANRORC reaction of in-situ generated 3-(phen

Chiral FLP-catalyzed asymmetric hydrogenation of 3-fluorinated chromones

The asymmetric hydrogenation of fluorinated olefins is an efficient pathway towards the synthesis of chiral fluorine-containing compounds. This paper described metal-free asymmetric hydrogenation of 3-fluorinated chromones with the use of readily availabl

Structure-Based Discovery of Pyrimidine Aminobenzene Derivatives as Potent Oral Reversal Agents against P-gp- And BCRP-Mediated Multidrug Resistance

Overexpression of ATP binding cassette (ABC) transporters, including P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), is an important factor leading to multidrug resistance (MDR) in cancer treatments. Three subclasses of dual inhibitors of P-gp and BCRP were designed based on the active moieties of BCRP inhibitors, tyrosine kinase inhibitors, and P-gp inhibitors, of which compound 21 possessed low cytotoxicity, high reversal potency, and good lipid distribution coefficient. 21 also increased the accumulation of Adriamycin (ADM) and Mitoxantrone (MX), blocked Rh123 efflux, and made no change in the protein expression of P-gp and BCRP. Importantly, coadministration of 21 can significantly improve the oral bioavailability of paclitaxel (PTX). It was also demonstrated that 21 significantly inhibited the growth of K562/A02 xenograft tumors by increasing the sensitivity of ADM in vivo. In summary, 21 has the potential to overcome MDR caused by P-gp and BCRP and to improve the oral bioavailability of PTX.

CuI/Cu(OSO2CF3)2 catalysed convenient approach to dichromenopyridines and triazole-thiazole appended chromone derivatives

A variety of new pentacyclic dichromenopyridines have been synthesized from 2-amino chromone and O-propargyloxy salicilaldehydes through intramolecular Povarov reaction using CuI/Cu(OSO2CF3)2 as a Lewis acid catalyst. The