1776-08-5

Upstream product

• 39079-62-4 chromone-3-carboxylic acid 
• 124-40-3 dimethyl amine 
• 118-93-4 o-hydroxyacetophenone 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 
• 17422-74-1 3-Formylchromone 
• 1776-09-6 3-bromochroman-4-one 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 491-38-3 1-benzopyran-4(4H)-one 
• 55168-26-8 trans-1-(2-Hydroxybenzoyl)-2-(4-oxo-4H-<1>benzopyran-3-yl)-ethylen 
• 135251-12-6 4-Hydroxy-5-(3-dimethylamino-2-propenoyl)-benzolsulfonylchlorid 
• 84200-61-3 4-Oxo-4H-<1>benzopyran-3-sulfinsaeure 
• 69-72-7 salicylic acid 
• 38518-76-2 2-amino-4H-1-benzopyran-4-one 
• 30779-85-2 3-benzyl-4H-1-benzopyran-4-one 
• 1335284-98-4 (E)-3-(dimethylamino)-1-(2-(pyridin-2-yloxy)phenyl)prop-2-en-1-one 
• 1335284-80-4 (E)-3-(dimethylamino)-1-(2-phenoxyphenyl)prop-2-en-1-one 
• 1335284-81-5 (E)-1-(2-(4-chlorophenoxy)phenyl)-3-(dimethylamino)prop-2-en-1-one 
• 1335284-83-7 (E)-1-(2-(p-tolyloxy)phenyl)-3-(dimethylamino)prop-2-en-1-one 
• 1335284-96-2 (E)-1-(2-(o-tolyloxy)phenyl)-3-(dimethylamino)prop-2-en-1-one 
• 1335284-82-6 (E)-1-(2-(4-bromophenoxy)phenyl)-3-(dimethylamino)prop-2-en-1-one 
• 1335284-84-8 (E)-1-(2-(4-methoxyphenoxy)phenyl)-3-(dimethylamino)prop-2-en-1-one 

Relevant academic research and scientific papers

1-Aryl-3-(dimethylamino)propenones: Strong proton acceptors for hydrogen bonds

Because of the electron-donating effects of their terminal dimethylamino groups, the carbonyl units of 1-aryl-3-(dimethylamino)prop-2-en-1-ones are excellent proton acceptors. Intra- and intermolecular hydrogen bonds formed by these species were investigated by structural techniques (X-ray and neutron diffraction), spectroscopy, and density functional calculations. Co-crystallization of a derivative bearing three (dimethylamino)prop-2-en-1-one units attached at one center in the presence of different proton donors produced one- and two-dimensional H-bridged polymers. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

Cascade reactions leading to the mechanism of action of vinaxanthone and xanthofulvin, natural products that drive nerve repair

The natural products vinaxanthone and xanthofulvin promote regeneration in animal models of spinal cord injury and corneal transplant. However, inhibition of the initially described biological target of these compounds, semaphorin 3A, does not fully account for the recovery demonstrated in vivo following administration of the natural products. Through chemical synthesis substantial quantities of both natural products have been accessed with early reaction development paving the way for synthesizing both compounds. The success of a model system, first disclosed herein, translated to the syntheses of both natural products. Following from this we also report for the first time the discovery of a new target of the natural products, the succinate receptor 1 (SUCNR1). Both natural products function as positive allosteric modulators of SUCNR1. As the first known allosteric modulators of SUCNR1, the compounds represent powerful new tools to understand the pharmacology of SUCNR1 and its control of growth and cellular defense.

X-ray diffraction and VT-NMR studies of (E)-3-(piperidinyl)-1-(2′-hydroxyphenyl)-prop-2-en-1-one

A series of 1-aryl-3-(cyclicamino)-prop-2-en-1-one analogs was synthesized from commercial acetophenones in 2 or 3 steps. Compound 6, (E)-3-(piperidinyl)-1-(2′-hydroxyphenyl)-prop-2-en-1-one, exhibited the unique shape and intensity of the Csp2

Mechanistic study of copper-catalyzed C-H Hydroxylation/C-S coupling by ESI-HR MS and DFT calculations

The reaction mechanism of Cu-catalyzed C-H hydroxylation/C-S coupling was studied using electrospray ionization high resolution mass spectrometry (ESI-HR MS) and density functional theory calculations (DFT). Notably, a series of CuI and CuIII complexes were observed as key intermediates and identified using ESI-HR MS. Furthermore, a catalyst cycle involving proton abstraction/oxidative addition/reductive elimination was proposed. This study is important and valuable with respect to C-H functionalization.

Synthesis of 3,4,5-Trisubstituted Isoxazoles via the ANRORC Rearrangement

A facile and versatile procedure for the synthesis of new functionalized derivatives of 3-benzyl-5-(2-hydroxyphenyl) isoxazole-4-carbaldehyde oxime has been described. The key step in the synthesis involves the ANRORC reaction of in-situ generated 3-(phen

A catalyst-free approach to 3-thiocyanato-4H-chromen-4-ones

A facile and efficient approach to 3-thiocyanato-4H-chromen-4-ones was realized at room temperature. In the presence of KSCN and K2S2O8, various enaminones underwent thiocyanation and cyclization, affording 3-thiocyanatochromenones in good yields. In addition, one-pot synthesis of 3-thiocyanatochromenones from 2-hydroxylacetophenones was also developed.

Chiral FLP-catalyzed asymmetric hydrogenation of 3-fluorinated chromones

The asymmetric hydrogenation of fluorinated olefins is an efficient pathway towards the synthesis of chiral fluorine-containing compounds. This paper described metal-free asymmetric hydrogenation of 3-fluorinated chromones with the use of readily availabl

An organic compound and an organic light emitting diode

The present invention relates to a novel organic compound and an organic light emitting device comprising the same. More particularly, the present invention relates to an organic compound having excellent lifetime, efficiency, electrochemical stability, a

Synthesis, antimicrobial and antiproliferative activities, molecular docking, and computational studies of novel heterocycles

We studied the reaction of enaminone 3 with some nitrogen nucleophiles to afford the corresponding pyrazole 4, isoxazole 5, and pyrimidine 6 derivatives, and the reactivity of enaminone 3 with heterocyclic amines to afford the corresponding fused pyrrolo[

TBN-triggered, manipulable annulations of: O -hydroxyarylenaminones for divergent syntheses of oximinochromanones and oximinocoumaranones

Divergent synthesis provides an indispensable route to rapid acquisition of structurally diverse chemical scaffolds from identical starting materials. Herein, we describe unprecedented divergent annulations of o-hydroxyarylenaminones promoted by tert-butyl nitrite (TBN) under mild conditions. Two different types of benzo-oxa-heterocycle, including oximinochromanones and oximinocoumaranones, were smoothly assembled with a broad substrate scope and good functional group compatibility.