1352544-76-3Relevant academic research and scientific papers
Discovery of inhibitors of plasminogen activator inhibitor-1: Structure-activity study of 5-nitro-2-phenoxybenzoic acid derivatives
Pandya, Vrajesh,Jain, Mukul,Chakrabarti, Ganes,Soni, Hitesh,Parmar, Bhavesh,Chaugule, Balaji,Patel, Jigar,Joshi, Jignesh,Joshi, Nirav,Rath, Akshyaya,Raviya, Mehul,Shaikh, Mubeen,Sairam, Kalapatapu V.V.M.,Patel, Harilal,Patel, Pankaj
scheme or table, p. 5701 - 5706 (2011/10/18)
Two novel series of 5-nitro-2-phenoxybenzoic acid derivatives are designed as potent PAI-1 inhibitors using hybridization and conformational restriction strategy in the tiplaxtinin and piperazine chemo types. The lead compounds 5a, 6c, and 6e exhibited potent PAI-1 inhibitory activity and favorable oral bioavailability in the rodents.
