1352755-89-5

Basic information

• Product Name: (S)-5-acetyl-4-(3-chlorophenyl)-6-methyl-3,4-dihydro-2H-pyran-2-one
• Synonyms: (S)-5-acetyl-4-(3-chlorophenyl)-6-methyl-3,4-dihydro-2H-pyran-2-one
• CAS NO: 1352755-89-5
• Molecular Weight: 264.708
• Mol File: 1352755-89-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-5-acetyl-4-(3-chlorophenyl)-6-methyl-3,4-dihydro-2H-pyran-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-5-acetyl-4-(3-chlorophenyl)-6-methyl-3,4-dihydro-2H-pyran-2-one(1352755-89-5)
• EPA Substance Registry System: (S)-5-acetyl-4-(3-chlorophenyl)-6-methyl-3,4-dihydro-2H-pyran-2-one(1352755-89-5)

Safety Data

• Hazardous Substances Data: 1352755-89-5(Hazardous Substances Data)

Upstream product

• 123-54-6 acetylacetone 
• 56578-37-1 3-(3-chlorophenyl)acrylaldehyde 
• 770-23-0 (E)-3-(3-chlorophenyl)propenal 
• 1352755-79-3 (Z)-2-bromo-3-(3-chlorophenyl)acrylaldehyde 

Relevant articles and documents

Enantioselective Synthesis of 3,4-Dihydropyran-2-ones via Phase-Transfer-Catalyzed Addition-Cyclization of Acetylacetone to Cinnamic Thioesters

Herein, we present the first example of synthesis of 3,4-dihydropyran-2-ones from cinnamic thioesters via a stereoselective phase-transfer-catalyzed domino Michael-cyclization reaction with acetylacetone. The reaction proceeded under the catalysis of Cinchona-derived quaternary ammonium phenoxide that, in combination with inorganic bases, provided 3,4-dihydropyran-2-ones in yields of up to 93% and enantioselectivities of up to 88% enantiomeric excess.

N-heterocyclic carbene-catalyzed enantioselective annulation of bromoenal and 1,3-dicarbonyl compounds

Highly enantioselective [3+3]-annulation reactions of bromoenals and 1,3-dicarbonyl compounds are reported. In addition, both enantiomers of the resultant dihydropyranone could be easily obtained by choosing N-heterocyclic carbenes (NHCs) with the same stereocenter but different substituents under the optimized reaction conditions. Copyright