1352756-01-4

Basic information

• Product Name: (R)-5-acetyl-4-(3-chlorophenyl)-6-methyl-3,4-dihydro-2H-pyran-2-one
• Synonyms: (R)-5-acetyl-4-(3-chlorophenyl)-6-methyl-3,4-dihydro-2H-pyran-2-one
• CAS NO: 1352756-01-4
• Molecular Weight: 264.708
• Mol File: 1352756-01-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-5-acetyl-4-(3-chlorophenyl)-6-methyl-3,4-dihydro-2H-pyran-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-5-acetyl-4-(3-chlorophenyl)-6-methyl-3,4-dihydro-2H-pyran-2-one(1352756-01-4)
• EPA Substance Registry System: (R)-5-acetyl-4-(3-chlorophenyl)-6-methyl-3,4-dihydro-2H-pyran-2-one(1352756-01-4)

Safety Data

• Hazardous Substances Data: 1352756-01-4(Hazardous Substances Data)

Upstream product

• 123-54-6 acetylacetone 
• 770-23-0 (E)-3-(3-chlorophenyl)propenal 
• 1352755-79-3 (Z)-2-bromo-3-(3-chlorophenyl)acrylaldehyde 

Relevant articles and documents

Enantioselective Synthesis of 3,4-Dihydropyran-2-ones via Phase-Transfer-Catalyzed Addition-Cyclization of Acetylacetone to Cinnamic Thioesters

Herein, we present the first example of synthesis of 3,4-dihydropyran-2-ones from cinnamic thioesters via a stereoselective phase-transfer-catalyzed domino Michael-cyclization reaction with acetylacetone. The reaction proceeded under the catalysis of Cinchona-derived quaternary ammonium phenoxide that, in combination with inorganic bases, provided 3,4-dihydropyran-2-ones in yields of up to 93% and enantioselectivities of up to 88% enantiomeric excess.