135283-68-0

Upstream product

• 135256-33-6 (2S,4S)-4-O-Benzyl-1,2-O-isopropylidene-5-hexene-1,2,4-triol 
• 32233-43-5 2-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]ethanol 
• 100-39-0 benzyl bromide 

Downstream Products

• 135256-34-7 (2S,4S,5RS)-4-O-Benzyl-1,2-O-isopropylidene-6-heptene-1,2,4,5-tetrol 
• 135256-41-6 (2S,4S,5S)-4-O-Benzyl-1,2-O-isopropylidene-5-phthalimido-6-heptene-1,2,4-triol 
• 135256-41-6 (2S,4S,5R)-4-O-Benzyl-1,2-O-isopropylidene-5-phthalimido-6-heptene-1,2,4-triol 
• 135256-42-7 (2S,4S,5R)-5-Acetamido-4-O-benzyl-1,2-O-isopropylidene-6-heptene-1,2,4-triol 
• 135256-42-7 (2S,4S,5S)-5-Acetamido-4-O-benzyl-1,2-O-isopropylidene-6-heptene-1,2,4-triol 
• 135256-48-3 (S)-1-[(S)-1-Benzyloxy-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl]-allylamine 
• 135256-48-3 (R)-1-[(S)-1-Benzyloxy-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl]-allylamine 

Relevant academic research and scientific papers

Convergent Synthesis of Kibdelone C

The synthesis of kibdelone C, a polycyclic natural xanthone isolated from a soil actinomycete, was achieved through a convergent approach. A 6?€-electrocyclization was applied to construct the highly substituted dihydrophenanthrenol fragment (B-C-D ring). InBr3-promoted lactonization was employed to build the isocoumarin ring, which served as a common precursor for the formation of isoquinolinone ring (A-B ring). A key DMAP-mediated oxa-Michael/aldol cascade reaction was developed to install the tetrahydroxanthone fragment (E-F ring). This approach provides a new solution to prepare its derivatives and structurally related natural products.

Total Synthesis of All Four Diastereomers of 2-Acetamido-2,4-dideoxy-D-hexapyranose as Potential Competitive Inhibitors of N-Acetylneuraminic Acid Synthase

A nine-step gram-scale total synthesis of all four diastereomers 3-6 of 2-acetamido-2,4-dideoxy-D-hexapyranose from aldehyde 9, a known derivative of (S)-malic acid, is described. Key Words: Deoxymannosamine / Carbohydrates, total synthesis of / Glycoprot