1352879-07-2Relevant academic research and scientific papers
Facile construction of vicinal quaternary and tertiary stereocenters via regio- and stereoselective organocatalytic michael addition to nitrodienes
Chauhan, Pankaj,Chimni, Swapandeep Singh
supporting information; experimental part, p. 3203 - 3212 (2012/01/04)
A highly regio- and stereoselective protocol for the synthesis of vicinal quaternary and tertiary stereocenters has been developed. The 6′-OH Cinchona alkaloids (BnCPN or BnCPD) at low catalyst loading (0.5-5 mol%) catalyze the Michael addition of trisubstituted carbon nucleophiles to nitrodienes in good to excellent yield (up to >99), high enantioselectivity (up to 99% ee) and high diastereoselectivity (up to >99:1 dr) under mild reaction conditions. Copyright
