90771-52-1

Upstream product

• 49678-08-2 3-(4-nitrophenyl)-propenal 
• 75-52-5 nitromethane 
• 1734-79-8 3-(4-nitrophenyl)-2-propenal 

Downstream Products

• 1352878-69-3 ethyl (S)-1-[(R,E)-1'-nitro-4'-(4''-nitrophenyl)but-3'-en-2'-yl]-2-oxocyclopentanecarboxylate 
• 1352879-07-2 ethyl (R)-1-[(S,E)-1'-nitro-4'-(4''-nitrophenyl)but-3'-en-2'-yl]-2-oxocyclopentanecarboxylate 
• 1427276-18-3 (1S,5S,6R,7S,E)-7-(4-nitrostyryl)-5-hydroxy-6-nitrobicyclo[3.2.1]octan-2-one 
• 63202-71-1 2-(4′-nitrophenyl)pyrrole 
• 1374343-97-1 (S,E)-3-(nitromethyl)-5-(4-nitrophenyl)-1-phenylpent-4-en-1-one 
• 1372793-33-3 (S,E)-4-(nitromethyl)-6-(4-nitrophenyl)hex-5-en-2-one 

Relevant academic research and scientific papers

Substituted pyrrole synthesis from nitrodienes

Though the Cadogan-Sundberg approach has been employed to synthesize a variety of indole and carbazole derivatives from nitroarenes, surprisingly, very little is reported for making pyrroles using the same approach from non-arene nitrodienes. Herein, we report a general method to synthesize substituted pyrroles, in one step with modest yields, from nitrodienes using triphenylphosphine in the presence of an Mo catalyst, bis(acetylaceto)dioxomolybdenum (VI). To shed light on the mechanism of this reaction, we performed DFT calculations using uB3LYP/6-31+G(d) basis set and observed that the reaction favors a path through a nitrene intermediate.

Organocatalytic "difficult" michael reaction of ketones with nitrodienes utilizing a primary amine-thiourea based on Di-tert-butyl aspartate

The primary amine-thiourea based on di-tert-butyl (S)-aspartate and (1R,2R)-1,2-diphenylethylene-1,2-diamine has been successfully employed in the "difficult" Michael reaction between aromatic ketones or acetone with nitrodienes. The high stability and re