1352903-61-7

Basic information

• Product Name: 3-Amino-5-bromo-1H-pyrazole-4-carboxylic acid ethyl ester
• Synonyms: 3-Amino-5-bromo-1H-pyrazole-4-carboxylic acid ethyl ester;3-amino-5-bromopyrazole-4-carboxylic acid ethyl ester
• CAS NO: 1352903-61-7
• Molecular Formula: C₆H₈BrN₃O₂
• Molecular Weight: 234.05062
• Mol File: 1352903-61-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 392.0±37.0 °C(Predicted)
• Appearance: /
• Density: 1.748±0.06 g/cm3(Predicted)
• PKA: 9.86±0.50(Predicted)
• CAS DataBase Reference: 3-Amino-5-bromo-1H-pyrazole-4-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-5-bromo-1H-pyrazole-4-carboxylic acid ethyl ester(1352903-61-7)
• EPA Substance Registry System: 3-Amino-5-bromo-1H-pyrazole-4-carboxylic acid ethyl ester(1352903-61-7)

Safety Data

• Hazardous Substances Data: 1352903-61-7(Hazardous Substances Data)

Usage

General Description

3-Amino-5-bromo-1H-pyrazole-4-carboxylic acid ethyl ester is a chemical compound with the molecular formula C8H9BrN4O2. It is an ethyl ester derivative of 3-amino-5-bromo-1H-pyrazole-4-carboxylic acid, which is commonly used as a building block in organic synthesis. 3-Amino-5-bromo-1H-pyrazole-4-carboxylic acid ethyl ester is a pyrazole derivative, which is a type of heterocyclic compound with a five-membered ring containing two nitrogen atoms. It is commonly used in the pharmaceutical industry as a starting material for the synthesis of various biologically active molecules. This chemical may also have other industrial or research applications, but its main use is as a precursor for the synthesis of other compounds.

Upstream product

• 1017802-87-7 3-acetylamino-5-bromo-1H-pyrazole-4-carboxylic acid ethyl ester 
• 15250-36-9 3-acetylamino-1H-pyrazole-4-carboxylic acid ethyl ester 
• 6994-25-8 3-amino-4-pyrazolecarboxylic acid ethyl ester 

Downstream Products

• 1352903-57-1 ethyl 2-bromo-7-phenyl-5-(p-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate 
• 1352903-72-0 C₃₀H₂₉N₃O₃ 
• 1352903-70-8 C₂₉H₂₄N₄O₃ 

Relevant articles and documents

Ultrasound assisted synthesis of 2-alkynyl pyrazolo[1,5-a]pyrimidines as potential anti-cancer agents

Background: The 2-alkynyl pyrazolo[1,5-a]pyrimidine derivatives have been explored as new and potential anti-proliferative agents. Methods: Ultrasound assisted synthesis of these compounds was carried out by using a multi-step method involving the H3PO3 mediated construction of pyrazolo[1,5-a]pyrimidine ring possessing a bromo group at C-2 position followed by Pd/C-Cu catalyzed alkynylation methodology as the key steps. Results and Conclusion: All these compounds showed selective growth inhibition of cancer cell lines when tested against MDA-MB 231 and K562 cell lines along with non-cancerous HEK293 cells.

(Pd/C-mediated)coupling-iodocyclization-coupling strategy in discovery of novel PDE4 inhibitors: A new synthesis of pyrazolopyrimidines

Pyranones fused with a pyrazolopyrimidine moiety were prepared via regioselective construction of pyranone ring using (Pd/C-mediated)coupling- iodocyclization followed by Sonogashira/Heck/Suzuki reactions. The pyrazolopyrimidine based reactant required was obtained via a new H 3PO3 mediated condensation reaction. This strategy has led to the discovery of a novel and potentially safe PDE4 inhibitor.