1352906-01-4

Upstream product

• 451-81-0 2-(2-fluorophenyl)acetyl chloride 
• 1407814-88-3 2-(2-fluorophenyl)-N-[(6-oxo-1,6-dihydropyridazin-3-yl)methyl]acetamide 
• 1407814-85-0 2-(2-fluorophenyl)-N-[(6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)methyl]acetamide 
• 79416-27-6 methyl aminolevulinate 
• 920285-96-7 C₅H₉N₃O 
• 144-55-8 sodium hydrogencarbonate 

Downstream Products

• 1407814-92-9 7-(2-fluorobenzyl)imidazo[1,5-b]pyridazine 
• 1407815-02-4 7-(2-fluorobenzyl)imidazo[1,5-b]pyridazine-5-carboximidamide acetate 

Relevant academic research and scientific papers

Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart Failure

The first-in-class soluble guanylate cyclase (sGC) stimulator riociguat was recently introduced as a novel treatment option for pulmonary hypertension. Despite its outstanding pharmacological profile, application of riociguat in other cardiovascular indications is limited by its short half-life, necessitating a three times daily dosing regimen. In our efforts to further optimize the compound class, we have uncovered interesting structure-Activity relationships and were able to decrease oxidative metabolism significantly. These studies resulting in the discovery of once daily sGC stimulator vericiguat (compound 24, BAY 1021189), currently in phase 3 trials for chronic heart failure, are now reported.

SUBSTITUTED AZABICYCLES AND USE THEREOF

The present application relates to novel substituted azabicycles, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.

SUBSTITUTED IMIDAZOPYRIDINES AND THE USE THEREOF

The present application relates to novel substituted imidazopyridazines, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prophylaxis of diseases and to their use for production of medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular disorders.

SUBSTITUTED IMIDAZOPYRIDINES AND IMIDAZOPYRIDAZINES AND THE USE THEREOF

The present application relates to novel substituted imidazopyridines and imidazopyridazines, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prophylaxis of diseases and to their use for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.