1353047-05-8Relevant academic research and scientific papers
Regioselective Synthesis of 2,3,4-Trisubstituted Pyrroles via Pd(II)-Catalyzed Three-Component Cascade Reactions of Amines, Alkyne Esters, and Alkenes
Zhang, Xu,Xu, Xuefeng,Chen, Gong,Yi, Wei
, p. 4864 - 4867 (2016)
A new, efficient, and versatile Pd(II)-catalyzed oxidative three-component cascade reaction of diverse amines, alkyne esters, and alkenes is disclosed for the direct synthesis of diverse 2,3,4-trisubstituted pyrroles with broad functional group tolerance and in good to excellent yields. This transformation is supposed to proceed through the cascade formation of C(sp2)-C(sp2) and C(sp2)-N bonds via Pd(II)-catalyzed regioselective alkene migratory insertion, intramolecular radical addition, and oxidation sequential processes.
