135308-80-4

Upstream product

• 106-49-0 p-toluidine 
• 60956-26-5 4-bromo-2-nitrotoluene 
• 108-24-7 acetic anhydride 

Downstream Products

• 929606-25-7 (2E)-3-(2-amino-4-bromophenyl)-2-(4-bromophenyl)prop-2-enoic acid 
• 929606-22-4 (2E)-3-(4-bromo-2-nitrophenyl)-2-(4-bromophenyl)prop-2-enoic acid 
• 1268163-53-6 tert-butyl (1E,4E)-8-(4-(dimethylcarbamoyl)phenyl)-4-(dipropylcarbamoyl)-3H-benzo[b]azepin-2-ylcarbamate 
• 1268162-81-7 (1E,4E)-2-amino-N-propyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide 
• 1268163-47-8 tert-butyl (1E,4E)-4-(propylcarbamoyl)-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepin-2-ylcarbamate 
• 1268163-46-7 (1E,4E)-2-(tert-butoxycarbonylamino)-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxylic acid 
• 1268163-34-3 methyl 4-((1E,4E)-2-amino-4-(dipropylcarbamoyl)-3H-benzo[b]azepin-8-yl)benzoate 
• 1268163-30-9 (1E,4E)-2-amino-8-(4-hydroxyphenyl)-N,N-dipropyl-3H-benzo[b]azepine-4-carboxamide 
• 1268163-73-0 tert-butyl (1E,4E)-4-(dipropylcarbamoyl)-8-(4-hydroxyphenyl)-3H-benzo[b]azepin-2-ylcarbamate 
• 1268163-65-0 (1E,4E)-ethyl 2-(tert-butoxycarbonylamino)-8-(3-cyanophenyl)-3H-benzo[b]azepine-4-carboxylate 
• 1268163-42-3 C₁₃H₁₁BrN₂O₄ 
• 926927-55-1 2-[1-(4-bromo-2-nitrophenyl)-(E)-methylidene]-3-cyanopropionic acid ethyl ester 
• 926927-54-0 (1E,4E)-ethyl 2-amino-8-[4-(pyrrolidine-1-carbonyl)-phenyl]-3H-benzo[b]azepine-4-carboxylate 
• 926927-58-4 (1E,4E)-ethyl-2-(tert-butoxycarbonylamino)-8-[4-(pyrrolidine-1-carbonyl)-phenyl]-3H-benzo[b]azepine-4-carboxylate 

Relevant academic research and scientific papers

An improved synthetic procedure for 6,6′-dibromoindigo (Tyrian purple)

Tyrian purple was the most precious dye of antiquity. We describe a simple synthetic procedure that yields the actual dye, 6,6′-dibromoindigo 1, in considerably improved overall yield and of analytical purity, also being amenable to scale-up.

SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS

Provided are compositions and methods useful for modulation of signaling through the Toll- like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.

SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS

Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.

NOVEL FUSED TRIAZOLONES AND THE USES THEREOF

This invention relates to novel compounds having the structural diagram (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of cancer.